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US 2026/0308136 A1Published application
Uric acid transporter agonist compound, pharmaceutical composition, and preparation method therefor and use thereof
AssigneeHangzhou E & J Biopharmaceutical Technology Co., Ltd.
InventorYuanjian XU
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Abstract
A uric acid transporter agonist compound has formula (I). The compound as a drug is hardly absorbed into an in-vivo circulation system, and has good uric acid transport protein agonistic activity. A pharmaceutical composition containing the compound of formula (I) and a preparation method for the compound of formula (I) are also provided.
Claims11
A compound represented by formula (I) and a racemate, a stereoisomer, a tautomer, an isotopically labeled compound, a nitrogen oxide, a solvate, a polymorph, a metabolite, an ester, a prodrug, or a pharmaceutically acceptable salt thereof:
- wherein
- R1 is selected from H, deuterium, and the following groups that are unsubstituted or optionally substituted with one, two, or more Ra:
- C1-12 alkyl, C3-12 cycloalkyl, 3- to 14-membered heterocyclyl, C6-14 aryl, 5- to 14-membered heteroaryl, and —C(O)—R11;
- R2 is selected from H, deuterium, and —C(O)—R21 that is unsubstituted or optionally substituted with one, two, or more Rb;
- R3 is selected from H, deuterium, and C1-12 alkyl, C6-14 aryl, and 5- to 14-membered heteroaryl that are unsubstituted or optionally substituted with one, two, or more Rc;
- R11 and R21 are identical or different and are independently selected from C1-12 alkyl, C2-12 alkenyl, C2-12 alkynyl, C3-12 cycloalkyl, 3- to 14-membered heterocyclyl, C6-14 aryl, and 5- to 14-membered heteroaryl;
- each of Ra, Rb, and Rc is identical or different and is independently selected from H, deuterium, halogen, CN, OH, C1-12 alkyl, and C1-12 alkyloxy.
4 more elements
Dependencies are inferred from the claim text.