Solid state salification of organic molecules

Abstract

In accordance with the purpose(s) of the present disclosure, as embodied and broadly described herein, the disclosure, in one aspect, relates to methods for producing a salt of a solid organic compound. The method involves (a) combining in the solid state the solid organic compound comprising one or more protonatable groups and an acid composition, wherein the amount of acid in the acid composition is about stoichiometric or less than stoichiometric relative to the one or more protonatable groups of the solid organic compound to produce a precursor mixture; and mixing the precursor mixture by mechanochemical milling to produce the salt of the solid organic compound. The methods described herein can produce salts of a variety of different organic molecules and is capable of being scaled up.

Dependencies are inferred from the claim text.