Compositions and methods for the treatment of ocular disorders
OwnerGregory Tochtrop, Philip Kiser +2inventors
InventorsGregory Tochtrop, Philip Kiser, Marco Bassetto, Mohsen Badiee
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Abstract
A method of treating an ocular disorder, such as light induced retinal degeneration, macular degeneration, Stargardt's disease, geographic atrophy, and retinitis pigmentosa, in a subject in need thereof, includes administering to the subject a therapeutically effective amount of a compound of formula (I), a 3-(cyclohexylmethoxy)-benzaldehyde moiety connected to a gamma-hydroxyamine moiety, which may be fluoro-substituted, as a retinoid isomerase (RPE65) inhibitor, or a pharmaceutically acceptable salt, tautomer, or solvate thereof.
Claims20
A compound of formula (I):
- or a pharmaceutically acceptable salt, tautomer, or solvate thereof, wherein:
- R1, R2, and R3 are each independently H or F;
- R4 and R5 are each independently H, D, or an alkyl, which is optionally substituted with one or more D or F, and wherein at least one of R4 or R5 is an alkyl, which is optionally substituted with one or more D or F.
A compound selected from:
- or a pharmaceutically acceptable salt, tautomer, or solvate thereof.
Dependencies are inferred from the claim text.