Two-in-one chromatography systems for use with small volume samples and with automated liquid handlers

Abstract

The disclosure provides 2-in-1 chromatography systems that comprise two different chromatography resins, such as a combination of two different resins selected from affinity resins, ion exchange resins, size exclusion resins, mixed modal resins and hydrophobic interaction resins. Chromatography systems provided by the disclosure include pipette tips, spin chromatography columns, mini-chromatography columns and filter plates that are loaded with the two different resins. The chromatography systems of the disclosure are suitable for use with small volume samples and with automated liquid handlers. Kits comprising the 2-in-1 chromatography system are also provided. Methods of using the 2-in-1 chromatography system, for example to purify and/or concentrate a compound of interest, are also provided.

Dependencies are inferred from the claim text.