Systems and methods for stereotactic guided radiation therapy using computer vision systems for patient specific body models

A system for generating a dynamic anatomical representation of an individual, the system comprising:

• a processor circuit, operatively coupled to a computer vision system, wherein the processor circuit is configured to:
• obtain a series of indexed three-dimensional (3D) medical imaging datasets of the individual, each dataset corresponding to a distinct phase of a respiratory cycle of the individual and depicting internal anatomical structures of the individual;
• generate a surface mesh model based on the series of indexed 3D imaging datasets, wherein the surface mesh model represents an external contour of the body of the individual;
• derive a skeletal mesh model from the surface mesh model using demographic data of the individual and a comparative anatomical data library, wherein the comparative anatomical data library includes a set of anatomical templates, and wherein deriving the skeletal mesh model comprises:
• using the demographic data to select an anatomical template that satisfies predefined thresholds for anatomical congruence with characteristics of the individual, and
• correlating external surface features from the surface mesh model with internal skeletal configurations of the selected anatomical template;
• obtain real-time image data depicting external surface features of the individual;
• and
• register the real-time image data with the skeletal mesh model to generate a dynamic anatomical representation that adapts to reflect changes in the pose of the individual.

A computer-implemented method for adapting radiation therapy based on positioning of a target region, the method comprising:

• obtaining a series of three-dimensional (3D) medical imaging datasets depicting an individual and a target region at different phases of a respiratory cycle of the individual;
• generating a dynamic anatomical model of the individual based on the 3D imaging datasets, wherein the dynamic anatomical model includes a representation of the target region, wherein generating comprises:
• constructing a surface mesh model representing an external contour of a body of the individual,
• deriving an internal skeletal model from the surface mesh model by correlating external surface features with internal skeletal configurations using a comparative anatomical data library, and
• registering the internal skeletal model with the representation of the target region from the 3D imaging datasets to create the dynamic anatomical model;
• based on the dynamic anatomical model, determining an alignment of the target region with a predetermined focal area of a therapeutic beam during different phases of the respiratory cycle;
• and
• controlling delivery of radiation therapy based on the alignment, wherein radiation is activated when the target region is within the predetermined focal area and deactivated when the target region moves out of the predetermined focal area.