Methods and compositions for wound care
OwnerAshley M. COMPAAN, Daniel NUNEZ +1inventors
InventorsAshley M. COMPAAN, Daniel NUNEZ, Douglas RODRIGUEZ
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Abstract
Disclosed are compositions comprising collagen and bioactive glass. In some aspects, the compositions further comprise a cross-linking agent. Disclosed are methods of making a sheet-like composition comprising preparing a collagen slurry; lyophilizing, cross-linking, and adding bioactive glass. Disclosed are methods of making a flowable composition comprising preparing a collagen slurry; lyophilizing, and adding bioactive glass.
Claims74
A composition comprising a) about 5-97%/wt collagen;
- b) about 0-15%/wt of a cross-linking agent;
- and c) about 1%-99%/wt bioactive glass.
The composition of any one of claims 1-11, wherein the bioactive glass has a porosity of up to 90%.
The composition of claim 300, wherein the therapeutic agent is a signaling protein, glycosaminoglycan, growth factor, antimicrobial agent, anti-inflammatory agent, analgesic, antibiotic, or a combination thereof.
The delivery device of claim 324, wherein the force required to eject the composition from a syringe applicator is less than 20 lbs.
A method of making a composition comprising
- a) preparing a collagen slurry;
- b) lyophilizing the collagen slurry to create a lyophilized collagen sample;
- c) crosslinking the lyophilized collagen slurry to form a cross-linked lyophilized collagen sample;
- and
- d) adding bioactive glass to the lyophilized cross-linked collagen sample.
The method of any one of claims 38-382, wherein the collagen is marine, bovine, porcine, ovine, vegan, equine or recombinant collagen.
The method of any one of claims 38-63, further comprising milling/homogenizing the lyophilized product.
A method of making a composition comprising
- a) preparing a collagen slurry;
- b) combining bioactive glass to the collagen slurry to form a bioactive glass-collagen slurry mix;
- and
- c) lyophilizing the bioactive glass-collagen slurry mix to form a lyophilized bioactive glass-collagen product.
Dependencies are inferred from the claim text.