Polymer-based therapeutics for inductive browning of fat
AssigneePurdue Research Foundation
InventorsMeng DENG, Chunhui JIANG, Liangju KUANG, Shihuan KUANG
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Abstract
This disclosure features the methods and compositions involving development of novel polymer-based therapeutics that induce browning of white adipocytes for the treatment of obesity and its associated metabolic diseases. The therapeutic effects are largely attributed to the promotion of brown and/or beige adipocyte development and function by leveraging adipocyte plasticity and polymer-based drug delivery systems. Both brown and beige adipocytes are densely packed with mitochondria which highly express uncoupling protein-1 (UCP1), a thermogenic protein mediating non-shivering thermogenesis.
Claims21
A therapeutic agent to selectively induce browning of adipocytes in a subject comprising:
- at least one compound or composition that induces the formation of brown and/or beige adipocytes;
- and
- a polymer that encapsulates the at least one compound or composition, wherein the compound or composition is encapsulated within the polymer via physical interactions or chemical interactions and configured to the proximity to white adipose tissue (WAT).
A method of delivering therapeutic amount of a drug to induce browning of adipocytes in a subject, comprising encapsulating the drug within a polymer matrix system, and releasing the drug at the proximity of white adipose tissue (WAT), wherein the drug is a compound or composition of that induces the formation of brown and/or beige adipocytes.
-28. (canceled)
Dependencies are inferred from the claim text.