Helicase degraders

A compound of Formula I

• or a pharmaceutically acceptable salt thereof;
• wherein:
• R1 is selected from monocyclic or bicyclic heteroaryl and monocyclic or bicyclic heterocycloalkyl, wherein each R1 optionally includes at least one ring nitrogen atom substituted with R7 as allowed by valency, and wherein R1 is optionally substituted with 1, 2, 3, or 4 groups selected from R8 as allowed by valency;
• Y is selected from a bond, bicyclic aryl, or bicyclic heteroaryl, wherein Y is optionally substituted with 1, 2, 3, or 4 groups independently selected from R2 as allowed by valency;
• X1 is selected from a bond or —NRa—;
• L is selected from a bond or -L1-L2-L3-L4-L5-L6-L7-;
• L1, L2, L3, L4, L5, L6, and L7 are independently selected from:
• a) a bond;
• b) —C(═O)—;
• c) —C≡C—;
• d) —NRa—;
• e) —O—;
• d) C1-C10 alkyl;
• e) cycloalkyl optionally substituted with 1, 2, 3, or 4 substituents independently selected from R3;
• f) heterocycloalkyl optionally substituted with 1, 2, 3, or 4 substituents independently selected from R4;
• g) aryl optionally substituted with 1, 2, 3, or 4 groups independently selected from R5;
• h) heteroaryl optionally substituted with 1, 2, 3, or 4 groups independently selected from R6;
• i) —NRa(C═O)—;
• j) —C(═O)NRa—;
• k) —C(═O)(C1-C6 alkyl)-;
• l) —(C1-C6 alkyl)C(═O)—;
• m) —(C1-C6 alkyl)NRa—;
• n) —NRa(C1-C6 alkyl)-;
• o) —(C1-C6 alkyl)O—;
• and
• p) —O(C1-C6 alkyl)-;
• X2 is selected from a bond, —NRa—, —O—, —C≡C—, —C(═O)—, —S(═O)2—, —C(═O)NRa—, —NRaC(═O)—, —S(═O)2NRa—, —NRaS(═O)2—, and —NRa(C═O)NRb—;
• Z is an E3 ubiquitin ligase binding moiety;
• R2 is selected at each occurrence from halogen, hydroxy, nitro, —NHRa, C1-C6 alkyl, C1-C6 haloalkyl, aryl, and oxo;
• R3 and R4 are independently selected at each occurrence from halogen, hydroxy, —NHRa, C1-C6 alkyl, C1-C6 haloalkyl and oxo;
• R5 and R6 are independently selected at each occurrence from halogen, hydroxy, nitro, —NHRa, C1-C6 alkyl, C1-C6 haloalkyl, and aryl;
• R7 is selected from:
• hydrogen;
• C1-C4 alkyl;
• C2-C6 alkenyl;
• C2-C6 alkynyl;
• C3-C6 cycloalkyl;
• C1-C6 alkoxy;
• and (Co-C6 alkyl)(aryl) which is optionally substituted with halogen, C1-C6 alkyl, or C1-C6 alkoxy;
• R8 is selected from:
• hydrogen;
• halogen;
• hydroxy;
• —NRaRb;
• nitro;
• C1-C6 alkyl;
• C1-C6 haloalkyl;
• C3-C6 cycloalkyl;
• C3-C6 heterocycloalkyl;
• C2-C6 alkenyl;
• C2-C6 alkynyl;
• C1-C6 alkoxy;
• (C0-C6 alkyl)(aryl) which is optionally substituted with halogen, C1-C6 alkyl, or C1-C6 alkoxy;
• and (Co-C6 alkyl)(heteroaryl) which is optionally substituted with halogen, C1-C6 alkyl, or C1-C6 alkoxy;
• and
• Ra and Rb are independently selected at each occurrence from hydrogen and C1-C6 alkyl.