US 2026/0306639 A1Published application

Degrader for decomposing cmet protein, and pharmaceutical composition comprising same

AssigneeInnocure Therapeutics, Inc.

InventorsHye Dong YOO, Young Jun SHIN, Bo Kyoung KIM, Dong Sik YANG, Seung Hoon KOOK

Life of this patent

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Abstract

A TPD compound is disclosed. The present invention relates to a novel PROTAC compound binding to a cMET protein and a pharmaceutical composition comprising the same. The present invention relates to a PROTAC compound that binds to a cMET protein, and since it can bind to a cMET protein and degrade it, it can be useful for the treatment or prevention of diseases related to cMET protein. The compound of the present invention has an excellent anticancer effect and can also induce the degradation of cMET proteins, which can show a therapeutic effect on cMET and related diseases.

Claims7

Dependent claims

A compound represented by the following Chemical Formula 1:

cMET Targeted Protein-Binding Moiety (P)-{Linker (L)}p-E3 Ligase-Binding Moiety (E) [Chemical Formula 1]
wherein,
E3 Ligase-Binding Moiety (E) is a compound represented by the following Chemical Formulas 2 to 6;
and
cMET Targeted Protein-Binding Moiety (P) is a compound represented with any of the following Chemical Formulas 3 to 7;
and
p is an integer of 0 or 1:
wherein,
X is hydrogen, halogen, amino, nitro, hydroxy, C1 to C6 straight or branched alkyl, or a 4 to 8 atom heterocyclic containing oxygen or nitrogen;
Q1 to Q4 are each independently C—F, C—Cl, C—H, C—X, or N, and at least any one of Q1 to Q4 is C—X;
Y is hydrogen, halogen, or a C1 to C6 a straight, branched or cyclic alkyloxy unsubstituted or substituted with halogen;
provided that when one of Q5 and Q6 is carbon atom, and the other is nitrogen atom, f
Z is carbon atom or nitrogen atom;
and
R1 is hydrogen, nitro, amino, carbonyl, C1 to C6 straight, branched or cyclic alkyl, or C1 to C6 straight, branched, or cyclic alkyl substituted with halogen.

12 more elements

A compound selected from the group consisting of the following compounds or a pharmaceutically acceptable salt thereof:

3-{6-[(4-{4-[(4-{2-[(2S)-2-{[5-(1-methyl-1H-pyrazole-4-yl)-1H-[1,2,3]triazolo[4,5-b]pyrazine-1-yl]methyl}morpholine-4-yl]pyrimidine-5-yl}phenyl)methyl]piperazine-1-yl}-4-oxobutyl)amino]-1-oxo-1,2-dihydropthalazine-2-yl}piperidine-2,6-dione;
3-{6-[(6-{4-[(4-{2-[(2S)-2-{[5-(1-methyl-1H-pyrazole-4-yl)-1H-[1,2,3]triazolo[4,5-b]pyrazine-1-yl]methyl}morpholine-4-yl]pyrimidine-5-yl}phenyl)methyl]piperazine-1-yl}-6-oxohexyl)amino]-1-oxo-1,2-dihydroptalazine-2-yl}piperidine-2,6-dione;
3-(6-((5-(4-(4-(2-((S)-2-((5-(1-methyl-1H-pyrazole-4-yl)-1H-[1,2,3]triazolo[4,5-b]pyrazine-1-yl)methyl)morpholino)pyrimidine-5-yl)benzyl)piperazine-1-yl)5-oxophtyl)amino)1-oxopthalazine-2(1H)-yl)piperidine-2,6-dione;
3-(6-((7-(4-(4-(2-((S)-2-((5-(1-methyl-1H-pyrazole-4-yl)-1H-[1,2,3]triazolo[4,5-b]pyrazine-1-yl)methyl)morpholino)pyrimidine-5-yl)benzyl)piperazine-1-yl)7-oxoheptyl)amino)-1-oxopthalazine-2(1H)-yl)piperidine-2,6-dione;
3-(6-((2-(2-(2-(2-(4-(4-(2-((S)-2-((5-(1-methyl-1H-pyrazole-4-yl)-1H-[1,2,3]triazolo[4,5-b]pyrazine-1-yl)methyl)morpholino)pyrimidine-5-yl)benzyl)piperazine-1-yl)-2-oxoethoxy)ethoxy)ethyl)amino)-1-oxopthalazine-2(1H)-yl)piperidine-2,6-dione;
3-[6-(12-{4-[(4-{2-[(2S)-2-{[5-(1-methyl-1H-pyrazole-4-yl)-1H-[1,2,3]triazolo[4,5-b]pyrazine-1-yl]methyl}morpholine-4-yl]pyrimidine-5-yl}phenyl)methyl]piperazine-1-yl}-12-oxo-4,7,10-trioxa-1-azadodecane-1-yl)-1-oxo-1,2-dihydroptalazine-2-yl]piperidine-2,6-dione;
3-[6-(15-{4-[(4-{2-[(2S)-2-{[5-(1-methyl-1H-pyrazole-4-yl)-1H-[1,2,3]triazolo[4,5-b]pyrazine-1-yl]methyl}morpholine-4-yl]pyrimidine-5-day}phenyl)methyl]piperazine-1-yl}-15-oxo-4,7,10,13-tetraoxa-1-azpentadecan-1-yl)-1-oxo-1,2-dihydroptalazine-2-yl]piperidine-2,6-dione;
3-(8-((2-(2-(3-(4-(4-(2-((S)-2-((5-(1-methyl-1H-pyrazole-4-yl)-1H-[1,2,3]triazolo[4,5-b]pyrazine-1-yl)methyl)morpholino)pyrimidin-5-yl})benzyl)piperazine-1-yl)-3-oxopropoxy)ethoxy)ethyl)amino)-1-oxopthalazine-2-(1H)-yl]piperidine-2,6-dione;
3-[8-(12-{4-[(4-{2-[(2S)-2-{[5-(1-methyl-1H-pyrazole-4-yl)-1H-[1,2,3]triazolo[4,5-b]pyrazine-1-yl]methyl}morpholine-4-yl]pyrimidine-5-yl}phenyl)methyl]piperazine-1-yl}-12-oxo-4,7,10-trioxa-1-azadodecane-1-yl)-1-oxo-1,2-dihydroptalazine-2-yl]piperidine-2,6-dione;
3-[8-(16-{4-[(4-{2-[(2S)-2-{[5-(1-methyl-1H-pyrazole-4-yl)-1H-[1,2,3]triazolo[4,5-b]pyrazine-1-yl]methyl}morpholine-4-yl]pyrimidine-5-yl}phenyl)methyl]piperazine-1-yl}-16-oxo-4,7,10,13-tetraoxa-1-azahexadecane-1-yl)-1-oxo-1,2-dihydropetalazine-2-yl]piperidine-2,6-dione;
3-{8-[(5-{4-[(4-{2-[(2S)-2-{[5-(1-methyl-1H-pyrazole-4-yl)-1H-[1,2,3]triazolo[4,5-b]pyrazine-1-yl]methyl}morpholine-4-il]pyrimidine-5-yl}phenyl)methyl]piperazine-1-yl}-5-oxopentyl)amino]-1-oxo-1,2-dihydroptalazine-2-yl}piperidine-2,6-dione;
3-{8-[(7-{4-[(4-{2-[(2S)-2-{[5-(1-methyl-1H-pyrazole-4-yl)-1H-[1,2,3]triazolo[4,5-b]pyrazine-1-yl]methyl}morpholine-4-yl]pyrimidine-5-yl}phenyl)methyl]piperazine-1-yl}-7-oxohepty)amino]-1-oxo-1,2-dihydroptalazine-2-yl}piperidine-2,6-dione;
3-[8-({2-[2-(3-{4-[(4-{2-[(2S)-2-{[5-(1-methyl-1H-pyrazole-4-yl)-1H-[1,2,3]triazolo[4,5-b]pyrazine-1-yl]methyl}morpholine-4-day]pyrimidine-5-day}phenyl)methyl]piperazine-1-yl}-3-oxopropoxy)ethoxy]ethyl}amino)-1-oxo-1,2-dihydrophthalazine-2-yl]piperidine-2,6-dione;
3-(8-((21-(4-(4-(2-(2-((S)-2-((5-(1-methyl-1H-pyrazole-4-yl)-1H-[1,2,3]triazolo[4,5-b]pyrazine-1-yl)methyl)morpholino)pyrimidine-5-yl)benzyl)piperazine-1-yl)21-oxo-3,6,9,12,15,18-hexaoxahenicosyl)amino)-1-oxopthalazine-2(1H)-yl)piperidine-2,6-dione;
3-(8-((4-(4-(4-(4-(2-((S)-2-((5-(1-methyl-1H-pyrazole-4-yl)-1H-[1,2,3]triazolo[4,5-b]pyrazine-1-yl)methyl)morpholino)pyrimidine-5-yl)benzyl)piperazine-1-yl)4-oxobutyl)amino)1-oxopthalazine-2(1H)-yl)piperidine-2,6-dione;
3-(8-((6-(4-(4-(2-((S)-2-((5-(1-methyl-1H-pyrazole-4-yl)-1H-[1,2,3]triazolo[4,5-b]pyrazine-1-yl)methyl)morpholino)pyrimidine-5-yl)benzyl)piperazine-1-yl)6-oxohexyl)amino)-1-oxopthalazine-2(1H)-yl)piperidine-2,6-dione;
3-(6-(4-((1-(4-(2-((S)-2-((5-(1-methyl-1H-pyrazole-4-yl)-1H-[1,2,3]triazolo[4,5-b]pyrazine-1-yl)methyl)morpholino)pyrimidine-5-il)benzyl)piperidine-4-il)methyl)piperazine-1-yl)-1-oxopthalazine-2(1H)-yl)piperidine-2,6-dione;
3-(4-methyl-8-((2-(4-(4-(2-(2-((S)-2-((5-(1-methyl-1H-pyrazole-4-yl)-1H-[1,2,3]triazolo[4,5-b]pyrazine-1-yl)methyl)morpholino)pyrimidine-5-yl)benzyl)piperazine-1-yl)-2-oxoethyl)amino)1-oxopthalazine-2(1H)-yl)piperidine-2,6-dione;
3-(6-(4-(2-(4-(4-(4-(2-((S)-2-((5-(1-methyl-1H-pyrazole-4-yl)-1H-[1,2,3]triazolo[4,5-b]pyrazine-1-yl)methyl)morpholino)pyrimidine-5-yl)benzyl)piperazine-1-yl)-2-oxoethyl)piperazine-1-yl)-1-oxopthalazine-2(1H)-yl)piperidine-2,6-dione;
3-((3-fluoro-4-(4-(4-(2-((S)-2-((5-(1-methyl-1H-pyrazole-4-yl)-1H-[1,2,3]triazolo[4,5-b]pyrazine-1-yl)methyl)morpholino)pyrimidine-5-yl)benzyl)piperazine-1-yl)phenyl)amino)piperidine-2,6-dione;
3-((2-fluoro-4-(4-(2-(4-(4-(2-(2-(2-((S)-2-((5-(1-methyl-1H-pyrazole-4-yl)-1H-[1,2,3]triazolo[4,5-b]pyrazine-1-yl)methyl)morpholino)pyrimidine-5-yl)benzyl)piperazine-1-il)acetyl)piperazine-1-yl)phenyl)amino)piperidine-2,6-dione;
3-((3-fluoro-4-(4-(2-(4-(4-(2-(2-(2-((S)-2-((5-(1-methyl-1H-pyrazole-4-yl)-1H-[1,2,3]triazolo[4,5-b]pyrazine-1-yl)methyl)morpholino)pyrimidine-5-yl)benzyl)piperazine-1-day)acetyl)piperazine-1-yl)phenyl)amino)piperidine-2,6-dione;
3-(1-(3-(5-((1-(1-(1-(3-(3-(2,6-dioxopiperidine-3-yl)-4-oxo-3,4-dihydrophthalazine-5-yl)amino)3,6,9,12-tetraoxapentadecan-15-oil)piperidine-4-yl)methoxy)pyrimidine-2-yl)benzyl)6-oxo-1,6-dihydropyridazine-3-yl)benzonitrile;
3-(1-(3-(5-((1-(2-(4-((1-(1-(2-(2-(2,6-dioxopiperidine-3-yl)-1-oxo-1,2-dihydropthalazine-6-yl)piperidine-4-yl)methyl)piperazine-1-yl)2-oxoethyl)piperidine-4-yl)methoxy)pyrimidine-2-yl)benzyl)6-oxo-1,6-dihydropyridazine-3-yl)benzonitrile;
3-(1-{[3-(5-{[1-(2-{4-[2-(2,6-dioxopiperidine-3-yl)-1-oxo-1,2-dihydropthalazine-6-yl]piperazine-1-il}acetyl)piperidine-4-yl]methoxy}pyrimidine-2-yl)phenyl]methyl}-6-oxo-1,6-dihydropyridazine-3-yl)benzonitrile;
3-(1-(3-(5-((1-((1-((1-(3-(2,6-dioxopiperidine-3-yl)-1-methyl-4-oxo-3,4-dihydropthalazine-5-yl)glysil)piperidine-4-yl)methyl)piperidine-4-il)methoxy)pyrimidine-2-yl)benzyl)6-oxo-1,6-dihydropyridazine-3-yl)benzonitrile;
3-(1-(3-(5-((1-((3-(3-(2,6-dioxopiperidine-3-yl)-1-methyl-4-oxo-3,4-dihydroptalazin-5-yl)glysil)piperidine-4-yl)methoxy)pyrimidine-2-yl)benzyl)6-oxo-1,6-dihydropyridazine-3-yl)benzonitrile;
3-(1-{[3-(5-{[1-(6-{[2-(2,6-dioxopiperidine-3-yl)-1-oxo-1,2-dihydroptalazine-6-yl]amino}hexanoyl)piperidine-4-il]methoxy}pyrimidine-2-yl)phenyl]methyl}-6-oxo-1,6-dihydropyridazine-3-yl)benzonitrile;
3-(1-{[3-(5-{[1-(7-{[2-(2,6-dioxopiperidin-3-yl)-1-oxo-1,2-dihydropthalazine-6-yl]amino}heptanoyl)piperidine-4-il]methoxy}pyrimidine-2-yl)phenyl]methyl}-6-oxo-1,6-dihydropyridazine-3-yl)benzonitrile;
3-{1-[(3-{5-[(1-{2-[2-(2-{[2-(2,6-dioxopiperidine-3-yl)-1-oxo-1,2-dihydrophthalazine-6-yl]amino}ethoxy)ethoxy]acetyl}piperidine-4-yl)methoxy]pyrimidine-2-yl}phenyl)methyl]-6-oxo-1,6-dihydropyridazine-3-yl}benzonitrile;
3-(1-{[3-(5-{[1-(2-{2-{2-(2-{2-{2-(2,6-dioxopiperidine-3-yl)-1-oxo-1,2-dihydropetthalazine-6-yl]amino}ethoxy)ethoxy}ethoxy}piperidine-4-il]methoxy}pyrimidine-2-yl)phenyl]methyl}-6-oxo-1,6-dihydropyridazine-3-yl)benzonitrile;
3-(1-{[3-(5-{[1-(14-{[2-(2,6-dioxopiperidine-3-yl)-1-oxo-1,2-dihydroptalazine-6-yl]amino}-3,6,9,12-tetratetradecanoyl)piperidine-4-yl]methoxy}pyrimidine-2-yl)phenyl]methyl}-6-oxo-1,6-dihydropyridazine-3-yl)benzonitrile;
3-(1-(3-(5-((1-(4-(2-(2,6-dioxopiperidin-3-yl)-4-methyl-1-oxo-1,2-dihydropthalazine-6-yl)amino)butanoyl)piperidine-4-yl)methoxy)pyrimidine-2-yl)benzyl)6-oxo-1,6-dihydropyridazine-3-yl)benzonitrile;
3-(1-(3-(5-((1-(6-(2-(2,6-dioxopiperidine-3-yl)-4-methyl-1-oxo-1,2-dihydropthalazine-6-yl)amino)hexanoyl)piperidine-4-yl)methoxy)pyrimidine-2-yl)benzonitrile-6-oxo-1,6-dihydropyridazine-3-yl)benzonitrile;
3-(1-(3-(5-((1-(2-(2-(2-(2-(2-(2-(2-(2-(2,6-dioxopiperidin-3-yl)-4-methyl-1-oxo-1,2-dihydroptalazine-6-yl)amino)ethoxy)ethoxy)acetyl)piperidine-4-il)methoxy)pyrimidine-2-yl)benzyl)6-oxo-1,6-dihydropyridazine-3-yl)benzonitrile;
3-(1-(3-(5-((1-(2-(2-(2-(2-(2-(2-(2-(2-(2-(2,6-dioxopiperidine-3-yl)-4-methyl-1-oxo-1,2-dihydroptalazine-6-yl)amino)ethoxy)ethoxy)ethoxy)acetyl)piperidine-4-yl)methoxy)pyrimidine-2-yl)benzonitrile;
3-(1-(3-(5-((1-(1-(14-((2-(2,6-dioxopiperidine-3-yl)-4-methyl-1-oxo-1,2-dihydropthalazine-6-yl)amino)3,6,9,12-tetradedecanoyl)piperidine-4-yl)methoxy)pyrimidine-2-yl)benzyl)6-oxo-1,6-dihydropyridazine-3-yl)benzonitrile;
3-(1-(3-(5-((1-(1-(1-(2-(2,6-dioxopiperidine-3-yl)-4-methyl-1-oxo-1,2-dihydropthalazine-6-yl)amino)3,6,9,12-tetraoxapentadecane-15-oil)piperidine-4-yl)methoxy)pyrimidine-2-yl)benzyl)6-oxo-1,6-dihydropyridazine-3-yl)benzonitrile;
3-(1-(3-(5-((1-(4-((4-(2-(2,6-dioxopiperidine-3-yl)-4-methyl-1-oxo-1,2-dihydropthalazine-6-yl)piperazine-1-yl)methyl)piperidine-1-carbonyl)piperidine-4-il)methoxy)pyrimidine-2-yl)benzyl)6-oxo-1,6-dihydropyridazine-3-yl)benzonitrile;
3-(1-(3-(5-((1-(2-(4-(3-(2-(2,6-dioxopiperidine-3-yl)-1-methyl-4-oxo-3,4-dihydropthalazine-6-ylpiperazine-1-yl)-2-oxoethyl)piperidine-4-yl)methoxy)pyrimidine-2-yl)benzyl)6-oxo-1,6-dihydropyridazine-3-yl)benzonitrile;
3-(1-(4-(5-((1-(2-(2-(2-(2-(2-(2,6-dioxopiperidine-3-yl)-4-methyl-1-oxo-1,2-dihydroptalazine-6-yl)piperazine-1-yl)acetyl)piperidine-4-yl)methoxy)pyrimidine-2-yl)benzyl)6-oxo-1,6-dihydropyridazine-3-yl)benzonitrile;
3-(1-(3-(5-((1-(1-(2-(4-(2-(2,6-dioxopiperidine-3-yl)-4-methyl-1-oxo-1,2-dihydropthalazine-6-yl)piperazine-1-il)acetyl)piperidine-4-il)methoxy)pyrimidine-2-yl)benzyl)6-oxo-1,6-dihydropyridazine-3-yl)benzonitrile;
3-(1-(3-(5-((1-(1-(2-(4-(2-(2,6-dioxopiperidine-3-yl)-4-methyl-1-oxo-1,2-dihydropthalazine-6-yl)piperazine-1-il)acetyl)piperidine-4-il)methoxy)pyrimidine-2-yl)benzyl)6-oxo-1,6-dihydropyridazine-3-yl)benzonitrile;
3-(1-(3-(5-((1-(5-(5-(5-(2-(2,6-dioxopiperidine-3-yl)-4-methyl-1-oxo-1,2-dihydropthalazine-6-yl)piperazine-1-yl)pentanoyl)piperidine-4-il)methoxy)pyrimidine-2-yl)benzyl)6-oxo-1,6-dihydropyridazine-3-yl)benzonitrile;
3-(1-{[3-(5-{[1-(2-{4-[2-(2,6-dioxopiperidine-3-yl)-4-methyl-1-oxo-1,2-dihydropthalazine-6-yl]piperazine-1-yl}-2-oxoethyl)piperidine-4-yl]methoxy}pyrimidin-2-yl)phenyl]methyl}-6-oxo-1,6-dihydropyridazine-3-yl)benzonitrile;
3-(1-(3-(5-((1-(2-(4-((4-(3-(2,6-dioxopiperidine-3-yl)-1-methyl-4-oxo-3-yl)piperazine-1-yl)methyl-1-yl)methyl-1-yl)piperidine-1-yl)-2-oxoethyl)piperidine-4-il)methoxy)pyrimidine-2-yl)benzonitrile;
3-(1-{[3-(5-{[1-(3-{4-[2-(2,6-dioxopiperidine-3-yl)-1-oxo-1,2-dihydropthalazine-6-yl]piperazine-1-il}propanoyl)piperidine-4-il]methoxy}pyrimidine-2-yl)phenyl]methyl}-6-oxo-1,6-dihydropyridazine-3-yl)benzonitrile;
3-(1-{[3-(5-{[1-(4-{4-[2-(2,6-dioxopiperidine-3-yl)-1-oxo-1,2-dihydroptalazine-6-yl]piperazine-1-yl}butanoyl)piperidine-4-il]methoxy}pyrimidine-2-yl)phenyl]methyl}-6-oxo-1,6-dihydropyridazine-3-yl)benzonitrile;
3-(1-{[3-(5-{[1-(5-{4-[2-(2,6-dioxopiperidin-3-yl)-1-oxo-1,2-dihydropthalazine-6-yl]piperazine-1-yl}pentanoyl)piperidine-4-yl]methoxy}pyrimidine-2-yl)phenyl]methyl}-6-oxo-1,6-dihydropyridazine-3-yl)benzonitrile;
3-(1-(3-(5-((1-(2-(4-((4-(4-(2-(2,6-dioxopiperidine-3-yl)-7-fluoro-4-methyl-1-oxo-1,2-dihydrophthalazine-6-yl)piperazine-1-yl)methyl)piperidine-1-yl)-2-oxoethyl)piperidine-4-il)methoxy)pyrimidine-2-yl)benzonitrile;
2-(4-(((2-(3-((3-(3-(3-cyanophenyl)-6-oxopridazine-1(6H)-yl)methyl)phenyl)pyrimidine-5-il)oxy)methyl)piperidine-1-yl)N-(5-(2-(2,6-dioxopiperidin-3-yl)-1-oxo-1,2-dihydropthalazine-6-yl)pent-4-phosphorus-1-yl)acetamide;
2-(4-(((2-(3-(3-(3-(3-(3-(3-cyanophenyl)-6-oxopyridazine-1(6H)-yl)methyl)phenyl)pyrimidine-5-yl)oxy)methyl)piperidine-1-yl)-N-(5-(2-(2,6-dioxopiperidin-3-yl)1-oxo-1,2-dihydropthalazine-6-yl)pentyl)acetamide;
2-(4-(((2-(3-((3-(3-(3-cyanophenyl)-6-oxopyridazine-1(6H)-yl)methyl)phenyl)pyrimidine-5-yl)oxy)methyl)piperidine-1-yl)N-(4-(4-(2-(2,6-dioxopiperidin-3-yl)4-methyl-1-oxo-1,2-dihydroptalazine-6-yl)piperazine-1-yl)phenyl)acetamide;
3-(1-(3-(5-((1-(2-(4-((1-(2-(1-(2-(2,6-dioxopiperidin-3-yl)-4-methyl-1-oxo-1,2-dihydropthalazine-6-yl)piperidine-4-yl)methyl)piperazine-1-il)acetyl)piperidine-4-il)methoxy)pyrimidine-2-yl)benzyl)6-oxo-1,6-dihydropyridazine-3-yl)benzonitrile;
3-(1-(3-(5-((1-(1-(2-(4-(3-(2,6-dioxopiperidine-3-yl)-1-methyl-4-oxo-3,4-dihydropthalazine-6-yl)piperazine-1-il)acetyl)piperidine-4-yl)methoxy)pyrimidine-2-yl)benzyl)6-oxo-1,6-dihydropyridazine-3-yl)benzonitrile;
3-(1-(3-(5-((1-(3-(3-(3-(3-(3-(2,6-dioxopiperidine-3-yl)-1-methyl-4-oxo-3,4-dihydropthalazine-6-yl)piperazine-1-yl)propanoyl)piperidine-4-il)methoxy)pyrimidine-2-yl)benzyl)6-oxo-1,6-dihydropyridazine-3-yl)benzonitrile;
3-(1-(3-(5-((1-(1-(4-(4-(3-(2,6-dioxopiperidine-3-yl)-1-methyl-4-oxo-3,4-dihydropthalazine-6-yl)piperazine-1-yl) butanoyl)piperidine-4-il)methoxy)pyrimidine-2-yl)benzyl)6-oxo-1,6-dihydropyridazine-3-yl)benzonitrile;
3-(1-(3-(5-((1-(5-(5-(5-(3-(3-(2,6-dioxopiperidine-3-yl)-1-methyl-4-oxo-3,4-dihydropthalazine-6-yl)piperazine-1-yl)pentanoyl)piperidine-4-yl)methoxy)pyrimidine-2-yl)benzyl)-6-oxo-1,6-dihydropyridazine-3-yl)benzonitrile;
3-(1-(3-(5-((1-(2-(4-(4-(2-(2-(2-(2,6-dioxopiperidine-3-yl)-4-methyl-1-oxo-1,2-dihydroptalazine-6-yl)piperazine-1-carbonyl)piperidine-1-il)acetyl)piperidine-4-il)methoxy)pyrimidine-2-yl)benzyl)6-oxo-1,6-dihydropyridazine-3-yl)benzonitrile;
3-(1-(3-(5-((1-(2-(4-((1-(1-(2-(2-(2,6-dioxopiperidine-3-yl)-4-methyl-1-oxo-1,2-dihydropthalazine-6-yl)piperidine-4-il)amino)piperidine-1-il)acetyl)piperidine-4-il)methoxy)pyrimidine-2-yl)benzyl)6-oxo-1,6-dihydropyridazine-3-yl)benzonitrile;
3-(1-(3-(5-((1-(2-(4-(2-(2,6-dioxopiperidine-3-yl)-1-oxo-1,2-dihydroptalazine-6-yl)piperazine-1-yl)2-oxoethyl)piperidine-4-il)methoxy)pyrimidine-2-yl)benzyl)-6-oxo-1,6-dihydropyridazine-3-yl)benzonitrile;
3-(1-(3-(5-((1-(1-(3-(3-(4-(2-(2,6-dioxopiperidine-3-yl)-1-oxo-1,2-dihydropthalazine-6-yl)piperazine-1-yl)-3-oxopropyl)piperidine-4-yl)methoxy)pyrimidine-2-yl)benzyl)-6-oxo-1,6-dihydropyridazine-3-yl)benzonitrile;
3-(1-{[3-(5-{[1-(3-{4-[2-(2,6-dioxopiperidine-3-yl)-4-methyl-1-oxo-1,2-dihydropthalazine-6-yl]piperazine-1-yl}-3-oxopropyl)piperidine-4-yl]methoxy}pyrimidine-2-yl)phenyl]methyl}-6-oxo-1,6-dihydropyridazine-3-yl)benzonitrile;
3-(1-(3-(5-((1-(3-(3-(4-(3-(2,6-dioxopiperidine-3-yl)-1-methyl-4-oxo-3,4-dihydropthalazine-6-yl)piperazine-1-yl)-3-oxopropyl)piperidine-4-yl)methoxy)pyrimidine-2-yl)benzyl)-6-oxo-1,6-dihydropyridazine-3-yl)benzonitrile;
3-(1-(3-(5-((1-(4-(4-(2-(2,6-dioxopiperidine-3-yl)-1-oxo-1,2-dihydropthalazine-6-yl) piperazine-1-yl)4-oxobutyl)piperidine-4-yl)methoxy)pyrimidine-2-yl)benzyl)-6-oxo-1,6-dihydropyridazine-3-yl)benzonitrile;
3-(1-(3-(5-((1-(4-(4-(2-(2,6-dioxopiperidine-3-yl)-4-methyl-1-oxo-1,2-dihydropthalazine-6-yl)piperazine-1-yl)-4-oxobutyl)piperidine-4-yl)methoxy)pyrimidine-2-yl)benzyl)-6-oxo-1,6-dihydropyridazine-3-yl)benzonitrile;
3-(1-(3-(5-((1-(4-(4-(3-(2,6-dioxopiperidine-3-yl)-1-methyl-4-oxo-3,4-dihydrophthalazine-6-yl)piperazine-1-yl)-4-oxobutyl)piperidine-4-yl)methoxy)pyrimidine-2-yl)benzyl)-6-oxo-1,6-dihydropyridazine-3-yl)benzonitrile;
3-(1-(3-(5-((1-(2-(4-((2R)-4-(2-(2-(2,6-dioxopiperidine-3-yl)-4-methyl-1-oxo-1,2-dihydrophthalazine-6-yl)morpholine-2-yl)methyl)piperazine-1-il)acetyl)piperidine-4-yl)methoxy)pyrimidine-2-yl)benzonitrile 6-oxo-1,6-dihydropyridazine-3-yl)benzonitrile;
3-(1-(3-(5-((1-(2-(4-((4-(4-(3-(2,6-dioxopiperidine-3-yl)-7-fluoro-1-methyl-4-oxo-3,4-dihydropetalazine-6-yl)piperazine-1-il)methylpiperidine-1-il)-2-oxoethyl)piperidine-4-il)methoxy)pyrimidine-2-yl)benzonitrile;
3-(1-(3-(5-((1-(2-(3-(3-(4-(2-(2-(2,6-dioxopiperidine-3-yl)-1-oxo-1,2-dihydrophthalazine-6-yl)piperazine-1-il)azetidine-1-yl)2-oxoethyl)piperidine-4-yl)methoxy)pyrimidine-2-yl)benzyl)6-oxo-1,6-dihydropyridazine-3-yl)benzonitrile;
3-(1-(3-(5-((1-(2-(4-(1-(1-(3-(2-(1-(3-(2,6-dioxopiperidin-3-yl)-1-methyl-4-oxo-3,4-dihydropthalazine-6-yl)piperidine-4-yl)piperazine-1-yl)-2-oxoethyl)piperidine-4-yl)methoxy)pyrimidine-2-yl)benzyl)6-oxo-1,6-dihydropyridazine-3-yl)benzonitrile;
3-(1-(3-(5-((1-(2-(4-((1-(1-(2-(4-(1-(3-(2,6-dioxopiperidine-3-yl)-1-methyl-4-oxo-3,4-dihydropthalazine-6-yl)piperidine-4-yl)methyl)piperazine-1-yl)-2-oxoethyl)piperidine-4-yl)methoxy)pyrimidine-2-yl)benzonitrile;
3-(1-(3-(5-((1-(2-(3-((4-(2-(3-(4-(2-(2,6-dioxopiperidine-3-yl)-4-methyl-1-oxo-1,2-dihydropthalazine-6-yl)piperazine-1-yl)methylazetidin-1-yl)-2-oxoethyl)piperidine-4-il)methoxy)pyrimidine-2-yl)benzyl)6-oxo-1,6-dihydropyridazine-3-yl)benzonitrile;
3-(1-(3-(5-((1-(2-(4-((1-(2-(1-(2-(2,6-dioxopiperidine-3-yl)-4-methyl-1-oxo-1,2-dihydropthalazine-6-yl)piperidine-4-yl)methyl)piperazine-1-yl)2-oxoethyl)piperidine-4-il)methoxy)pyrimidine-2-yl)benzonitrile;
3-(1-(3-(5-((1-(1-(2-(4-(4-(2-(2-(2-(2,6-dioxopiperidine-3-yl)-4-methyl-1-oxo-1,2-dihydropthalazine-6-yl)piperazine-1-yl)piperidine-1-yl)piperidine-1-yl)2-oxoethyl)piperidine-4-yl)methoxy)pyrimidine-2-yl)benzyl)6-oxo-1,6-dihydropyridazine-3-yl)benzonitrile;
N-(3-(2-(4-(((2-(3-((3-(3-(3-cyanophenyl)-6-oxopridazine-1(6H)-yl)methyl)phenyl)pyrimidine-5-yl)oxy)methyl)piperidine-1-yl) acetamido)propyl)-1-(3-(2,6-dioxopiperidine-3-yl)-1-methyl-4-oxo-3,4-dihydroptalazine-6-yl)piperidine-4-carboxamide;
3-(1-(3-(5-((1-(2-(4-((1-(1-(3-(2,6-dioxopiperidin-3-yl)-1-methyl-4-oxo-3,4-dihydropthalazine-6-yl)piperidine-4-il)methyl)piperazine-1-il)acetyl)piperidine-4-il)methoxy)pyrimidine-2-yl)benzyl)6-oxo-1,6-dihydropyridazine-3-yl)benzonitrile;
3-(1-(3-(5-((1-((4-(4-(2-(2,6-dioxopiperidine-3-yl)-4-methyl-1-oxo-1,2-dihydropthalazine-6-yl)piperazine-1-yl)phenyl)glycyl)piperidine-4-il)methoxy)pyrimidine-2-yl)benzyl)6-oxo-1,6-dihydropyridazine-3-yl)benzonitrile;
3-(1-(3-(5-((1-(5-(5-(5-(4-(2-(2,6-dioxopiperidine-3-yl)-4-methyl-1-oxo-1,2-dihydropthalazine-6-yl)piperazine-1-yl)-5-oxopentyl)piperidine-4-yl)methoxy)pyrimidine-2-yl)benzyl)6-oxo-1,6-dihydropyridazine-3-yl)benzonitrile;
3-(1-(3-(5-((1-(5-(5-(5-(3-(2,6-dioxopiperidine-3-yl)-1-methyl-4-oxo-3,4-dihydropthalazine-6-yl)piperazine-1-yl)-5-oxopentil)piperidine-4-yl)methoxy)pyrimidine-2-yl)benzyl)-6-oxo-1,6-dihydropyridazine-3-yl)benzonitrile;
3-(1-(3-(5-((1-(5-(5-(4-(2-(2,6-dioxopiperidin-3-yl)-1-oxo-1,2-dihydropthalazine-6-yl)piperazine-1-yl)5-oxopentyl)piperidine-4-yl)methoxy)pyrimidine-2-yl)benzyl)-6-oxo-1,6-dihydropyridazine-3-yl)benzonitrile;
3-(1-(3-(5-((1-(2-(3-((4-(2-(2,6-dioxopiperidine-3-yl)-4-methyl-1-oxo-1,2-dihydropthalazine-6-yl)piperazine-1-il)methylazetidin-1-il)acetyl)piperidine-4-il)methoxy)pyrimidine-2-yl)benzyl)6-oxo-1,6-dihydropyridazine-3-yl)benzonitrile;
3-(1-(3-(5-((1-(2-((6R)-6-((4-(2-(2,6-dioxopiperidin-3-yl)-4-methyl-1-oxo-1,2-dihydropthalazine-6-yl)piperazine-1-yl)methyl)1,3-oxajinan-3-yl)acetyl)piperidine-4-yl)methoxy)pyrimidine-2-yl)benzonitrile 6-oxo-1,6-dihydropyridazine-3-yl)benzonitrile;
3-(1-(3-(5-((1-(2-(4-(4-(2-(2-(2-(2,6-dioxopiperidine-3-yl)-4-methyl-1-oxo-1,2-dihydrophthalazine-6-yl)piperazine-1-il)piperidine-1-il)piperidine-1-il)acetyl)piperidine-4-il)methoxy)pyrimidine-2-yl)benzyl)6-oxo-1,6-dihydropyridazine-3-yl)benzonitrile;
3-(1-(3-(5-((1-(2-(4-(4-(2-(2-(2-(2-(2,6-dioxopiperidine-3-yl)-4-methyl-1-oxo-1,2-dihydropthalazine-6-yl)piperazine-1-il)methyl)piperidine-1-il)acetyl)piperidine-4-il)methoxy)pyrimidine-2-yl)benzyl)6-oxo-1,6-dihydropyridazine-3-yl)benzonitrile;
3-(1-(3-(5-((1-(2-(1-(1-(4-(2-(2-(2-(2,6-dioxopiperidine-3-yl)-4-methyl-1-oxo-1,2-dihydropthalazine-6-yl)piperazine-1-carbonyl)azetidine-3-il)acetyl)piperidine-4-yl)methoxy)pyrimidine-2-yl)benzyl)6-oxo-1,6-dihydropyridazine-3-yl)benzonitrile;
3-(1-(3-(5-((1-(2-((2R)-2-((4-(2-(2,6-dioxopiperidine-3-yl)-4-methyl-1-oxo-1,2-dihydropetalazine-6-yl)piperazine-1-yl)methyl)morpholino)2-oxoethyl)piperidine-4-yl)methoxy)pyrimidine-2-yl)benzonitrile;
3-(1-(3-(5-((1-((4-(4-(3-(2,6-dioxopiperidine-3-yl)-1-methyl-4-oxo-3,4-dihydropthalazine-6-yl)piperazine-1-yl)phenyl)glycy)piperidine-4-il)methoxy)pyrimidine-2-yl)benzyl)6-oxo-1,6-dihydropyridazine-3-yl)benzonitrile;
3-(1-(3-(5-((1-(2-(4-(1-(3-(2-(1-(3-(2,6-dioxopiperidine-3-yl)-1-methyl-4-oxo-3,4-dihydropthalazine-6-yl)piperidine-4-il) piperazine-1-il)acetyl)piperidine-4-il)methoxy)pyrimidine-2-yl)benzyl)6-oxo-1,6-dihydropyridazine-3-yl)benzonitrile;
3-(1-(3-(5-((1-(2-(4-((2R)-4-(3-(2,6-dioxopiperidine-3-yl)-1-methyl-4-oxo-3,4-dihydrophthalazine-6-yl)morpholine-2-yl)methyl)piperazine-1-il)acetyl)piperidine-4-il)methoxy)pyrimidine-2-yl)benzonitrile;
3-(1-(3-(5-((1-(2-(4-((4-(2-(2,6-dioxopiperidine-3-yl)-7-fluoro-4-methyl-1-oxo-1,2-dihydropthalazine-6-yl)piperazine-1-il)methyl)piperidine-1-il)acetyl)piperidine-4-il)methoxy)pyrimidine-2-yl)benzonitrile 6-oxo-1,6-dihydropyridazine-3-yl)benzonitrile;
3-(1-{[3-(5-{[1-(2-{4-[2-(2,6-dioxopiperidine-3-yl)-1-oxo-1,2-dihydroptalazine-6-yl]piperazine-1-il}ethyl)piperidine-4-yl]methoxy}pyrimidine-2-yl)phenyl]methyl}-6-oxo-1,6-dihydropyridazine-3-yl)benzonitrile;
3-(1-{[3-(5-{[1-(2-{4-[2-(2,6-dioxopiperidine-3-yl)-4-methyl-1-oxo-1,2-dihydropthalazine-6-yl]piperazine-1-il}ethyl)piperidine-4-il]methoxy}pyrimidin-2-yl)phenyl]methyl}-6-oxo-1,6-dihydropyridazine-3-yl)benzonitrile;
3-(1-{[3-(5-{[1-(2-{4-[3-(2,6-dioxopiperidin-3-yl)-1-methyl-4-oxo-3,4-dihydropthalazine-6-yl]piperazine-1-il}ethyl)piperidine-4-il]methoxy}pyrimidine-2-yl)phenyl]methyl}-6-oxo-1,6-dihydropyridazine-3-yl)benzonitrile;
3-(1-(4-(5-((1-(5-(5-(2-(2,6-dioxopiperidine-3-yl)-1-oxo-1,2-dihydroptalazine-5-yl)pentyl)piperidine-4-yl)methoxy)pyrimidin-2-yl)benzyl)6-oxo-1,6-dihydropyridazine-3-yl)benzonitrile;
3-(1-(4-(5-((1-(5-(5-(2,6-dioxopiperidine-3-yl)-1-oxo-1,2-dihydropetalazine-5-yl)pent-4-in-yl)piperidine-4-yl)methoxy)pyrimidine-2-yl)benzonitrile-6-oxo-1,6-dihydropyridazine-3-yl)benzonitrile;
3-(1-(3-(5-((1-(5-(5-(2-(2,6-dioxopiperidine-3-yl)-1-oxo-1,2-dihydrophthalazine-6-yl)pentyl)piperidine-4-yl)methoxy)pyrimidine-2-yl)benzyl)6-oxo-1,6-dihydropyridazine-3-yl)benzonitrile;
3-(1-(3-(5-((1-(5-(5-(2-(2,6-dioxopiperidine-3-yl)-1-oxo-1,2-dihydrophthalazine-6-yl)pent-4-phospho-1-yl)piperidine-4-yl)methoxy)pyrimidine-2-yl)benzyl)-6-oxo-1,6-dihydropyridazine-3-yl)benzonitrile;
3-(1-(3-(5-((1-(2-(2-(2-(2-(2-(3-(2-(2,6-dioxopiperidine-3-yl)-1-oxo-1,2-dihydropthalazine-5-yl)prop-2-phosphorus-1-yl)oxy)ethoxy)ethoxy)ethyl)piperidine-4-il)methoxy)pyrimidine-2-yl)benzyl)6-oxo-1,6-dihydropyridazine-3-yl)benzonitrile;
3-(1-(3-(5-((1-(2-((2R)-2-((4-(2-(2-(2-(dioxopiperidine-3-yl)-4-methyl-1-oxo-1,2-dihydroptalazine-6-yl)piperazine-1-yl)methyl)morphopolino)ethyl)piperidine-4-il)methoxy)pyrimidine-2-yl)benzyl)6-oxo-1,6-dihydropyridazine-3-yl)benzonitrile;
3-(1-(3-(5-((1-(1-(2-(4-(4-(2-(2-(2,6-dioxopiperidine-3-yl)-4-methyl-1-oxo-1,2-dihydropthalazine-6-yl)piperazine-1-il)piperidine-1-il)ethyl)piperidine-4-il)methoxy)pyrimidine-2-yl)benzyl)6-oxo-1,6-dihydropyridazine-3-yl)benzonitrile;
3-(1-(3-(5-((1-(2-(4-(4-(4-(2-(2,6-dioxopiperidine-3-yl)-7-fluoro-4-methyl-1-oxo-1,2-dihydrophthalazine-6-yl)piperazine-1-il)methyl)piperidine-1-il)ethyl)piperidine-4-il)methoxy)pyrimidine-2-yl)benzonitrile-6-oxo-1,6-dihydropyridazine-3-yl)benzonitrile;
3-(1-(3-(5-((1-(2-(4-((4-(4-(2-(2,6-dioxopiperidine-3-yl)-4,7-dimethyl-1-oxo-1,2-dihydrophthalazine-6-yl)piperazine-1-yl)methyl)piperidine-1-il)ethyl)piperidine-4-il)methoxy)pyrimidine-2-yl)benzonitrile 6-oxo-1,6-dihydropyridazine-3-yl)benzonitrile 3-(1-(3-(5-((1-(2-(4-((4-(3-(2,6-dioxopiperidine-3-yl)-1-methyl-4-oxo-3,4-dihydropthalazine-6-yl)piperazine-1-il)methyl)piperidine-1-il)ethyl)piperidine-4-il)methoxy)pyrimidine-2-yl)benzonitrile-6-oxo-1,6-dihydropyridazine-3-yl)benzonitrile;
3-(1-(3-(5-((1-(1-(2-(3-(4-(2-(2-(2,6-dioxopiperidine-3-yl)-4-methyl-1-oxo-1,2-dihydropthalazine-6-yl)piperazine-1-il)azetidine-1-il)ethyl)piperidine-4-il)methoxy)pyrimidine-2-yl)benzyl)6-oxo-1,6-dihydropyridazine-3-yl)benzonitrile;
3-(1-(3-(5-((1-(2-(4-((4-(3-(2,6-dioxopiperidine-3-yl)-7-fluoro-1-methyl-4-oxo-3,4-dihydroptalazine-6-yl)piperazine-1-il)methyl)piperidine-1-il)ethyl)piperidine-4-il)methoxy)pyrimidine-2-yl)benzonitrile;
3-(1-(3-(5-((1-(4-((2,6-dioxopiperidine-3-yl)amino)-2-fluorophenyl)piperidine-4-yl)methoxy)pyrimidine-2-yl)benzyl)6-oxo-1,6-dihydropyridazine-3-yl)benzonitrile;
3-{1-[(3-{5-[(1-{[1-(2,6-dioxopiperidine-3-yl)-1H-1,2,3-triazole-4-yl]methyl}piperidine-4-yl)methoxy]pyrimidine-2-yl}phenyl)methyl]-6-oxo-1,6-dihydropyridazine-3-yl}benzonitrile;
3-(1-(3-(5-(4-((1-(4-((2,6-dioxopiperidine-3-yl)amino)2-fluorophenyl)piperidine-4-yl)methyl)piperazine-1-il)pyrimidine-2-yl)benzyl)-6-oxo-1,6-dihydropyridazine-3-yl)benzonitrile;
3-(1-(3-(5-((1-((1-(1-((1-((2,6-dioxopiperidin-3-yl)amino)2-fluorophenyl)azetidine-3-yl)methyl)piperidine-4-yl)methoxy)pyrimidine-2-yl)benzyl)6-oxo-1,6-dihydropyridazine-3-yl)benzonitrile;
3-(1-(3-(5-((1-(2-(4-((4-((2,6-dioxopiperidine-3-yl)amino)2-fluorophenyl)piperazine-1-yl)ethyl)piperidine-4-yl)methoxy)pyrimidine-2-yl)benzyl)6-oxo-1,6-dihydropyridazine-3-yl)benzonitrile;
3-(1-(3-(5-(3-((4-((2,6-dioxopiperidin-3-yl)amino)2-(4-((2,6-dioxopiperidin-3-yl)amino)2-fluorophenyl)piperazine-1-yl)methyl)phenyl)pyrimidine-2-yl)benzyl)-6-oxo-1,6-dihydropyridazine-3-yl)benzonitrile;
3-(1-(3-(5-((1-(2-(4-((2,6-dioxopiperidine-3-yl)amino)-3-fluorophenyl)piperazine-1-yl)-2-oxoethyl)piperidine-4-yl)methoxy)pyrimidine-2-yl)benzonitrile;
3-(1-{[3-(5-{[1-(2-{4-[(4-{4-[(2,6-dioxopiperidine-3-yl)amino]-2-fluorophenyl}piperazine-1-yl)methyl]piperidine-1-yl}-2-oxoethyl)piperidine-4-il]methoxy}pyrimidine-2-yl)phenyl]methyl}-6-oxo-1,6-dihydropyridazine-3-yl)benzonitrile;
3-(1-(3-(5-(3-((4-(5-(2,6-dioxopiperidine-3-yl)pyridine-2-yl)piperazine-1-yl)methyl)phenyl)pyrimidine-2-yl)benzyl)6-oxo-1,6-dihydropyridazine-3-yl)benzonitrile;
3-(1-(3-(5-(3-((4-((4-((4-(4-((4-((2,6-dioxopiperidine-3-yl)amino)2-fluorophenyl)piperazine-1-il)methyl)piperidine-1-il)methyl)phenyl)pyrimidine-2-yl)benzyl)6-oxo-1,6-dihydropyridazine-3-yl)benzonitrile;
3-(1-{[3-(5-{[1-(2-{4-[(1-{4-[(2,6-dioxopiperidine-3-yl)amino]-2-fluorophenyl}piperidine-4-yl)methyl]piperazine-1-yl}-2-oxoethyl)piperidine-4-il]methoxy}pyrimidine-2-yl)phenyl]methyl}-6-oxo-1,6-dihydropyridazine-3-yl)benzonitrile;
3-(1-(3-(5-((1-(1-(2-(4-((4-((2,6-dioxopiperidin-3-yl)amino)2-fluorophenyl)piperazine-1-yl)acetyl)piperidine-4-yl)methoxy)pyrimidine-2-yl)benzyl)6-oxo-1,6-dihydropyridazine-3-yl)benzonitrile;
3-(1-(3-(5-(4-((1-(3-(3-(2,6-dioxopiperidine-3-yl)-1-methyl-4-oxo-3,4-dihydropthalazine-6-yl)piperidine-4-yl)methyl)piperazine-1-il)pyrimidine-2-yl)benzyl)6-oxo-1,6-dihydropyridazine-3-yl)benzonitrile;
3-(1-(3-(5-(4-((1-(2-(2,6-dioxopiperidine-3-yl)-1-oxo-1,2-dihydropthalazine-6-yl)piperidine-4-yl)methyl)piperazine-1-il)pyrimidine-2-yl)benzyl)6-oxo-1,6-dihydropyridazine-3-yl)benzonitrile;
3-(1-(3-(5-(4-((1-(3-(3-(2,6-dioxopiperidine-3-yl)-4-oxo-3,4-dihydrophthalazine-6-yl)piperidine-4-yl)methyl)piperazine-1-il)pyrimidine-2-yl)benzonitrile;
3-(1-(3-(5-(4-(3-(3-(4-(4-(2-(2,6-dioxopiperidine-3-yl)-1-oxo-1,2-dihydrophthalazine-6-yl)piperazine-1-yl)-2-hydroxypropyl)piperazine-1-day)pyrimidine-2-yl)benzyl)-6-oxo-1,6-dihydropyridazine-3-yl)benzonitrile;
and
3-(1-(3-(5-(4-(3-(3-(4-(4-(2-(2,6-dioxopiperidin-3-yl)-4-methyl-1-oxo-1,2-dihydropthalazine-6-yl)piperazine-1-yl)-2-hydroxypropyl)piperazine-1-il)pyrimidine-2-yl)benzo) 6-oxo-1,6-dihydropyridazine-3-yl)benzonitrile.

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Abstract