Chimeric receptors
AssigneeSt. Jude Children's Research Hospital
InventorsStephen GOTTSCHALK, Matthew BELL, Shannon LANGE
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Abstract
The application relates to chimeric receptors, particularly chimeric receptors comprising homodimeric polypeptides. Also disclosed are the uses of these receptors in tumor immunotherapy adoptive cell therapy). The application further relates to methods of genetically modifying therapeutic immune cells resulting in an enhanced immune response against a target antigen. Them application further relates to therapeutic cells that express the chimeric receptors and methods for treating patients using the modified therapeutic cells.
Claims179
A chimeric receptor which is a homodimer comprising two polypeptide monomers, wherein each polypeptide monomer comprises:
- i) an extracellular region comprising at least one homodimerizing motif;
- ii) a transmembrane region;
- and
- iii) an intracellular region comprising at least one signaling region derived from a cell-surface receptor or a signal transducing adaptor protein, or a portion or variant thereof.
A chimeric receptor which is a homodimer comprising two polypeptide monomers, wherein each polypeptide monomer comprises:
- i) an extracellular region comprising a means for homodimerizing the two polypeptide monomers;
- ii) a transmembrane region comprising a means for joining the intracellular regions with extracellular region;
- and
- iii) an intracellular region comprising a means for enhancing effector function of an immune cell.
A chimeric receptor which is a homodimer comprising two polypeptide monomers, wherein each polypeptide monomer comprises:
- i) an extracellular region comprising a means for homodimerizing the two polypeptide monomers;
- ii) a transmembrane region;
- and
- iii) an intracellular region comprising at least one signaling region derived from a cell-surface receptor or a signal transducing adaptor protein, or a portion or variant thereof.
A chimeric receptor which is a homodimer comprising two polypeptide monomers, wherein each polypeptide monomer comprises:
- i) an extracellular region comprising at least one homodimerizing motif;
- ii) a transmembrane region;
- and
- iii) an intracellular region comprising a means for enhancing effector function of an immune cell.
A chimeric receptor comprising i) an extracellular region;
- ii) a transmembrane region;
- and iii) an intracellular region comprising at least one signaling region derived from a cell-surface receptor or a signal transducing adaptor protein, or a portion or variant thereof, the improvement comprising said extracellular region comprising at least one homodimerizing motif.
A chimeric receptor, the improvement comprising two transmembrane polypeptide monomers each comprising i) an extracellular region comprising at least one homodimerizing motif and ii) an intracellular region comprising at least one signaling region derived from a cell-surface receptor or a signal transducing adaptor protein, or a portion or variant thereof.
Dependencies are inferred from the claim text.