Mucosal vaccines against tuberculosis
AssigneeUniversity of Houston System
InventorsNavin Varadarajan, K M Samiur Rahman Sefat, Monish Kumar
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Abstract
Embodiments of the present disclosure pertain to a composition that includes a particle, an antigen, and a modulator. In some embodiments, the modulator includes, without limitation, an agonist, an activator of the immune system, or combinations thereof. In some embodiments, the antigen is operable to elicit an immune response in a subject against Mycobacterium tuberculosis. Additional embodiments of the present disclosure pertain to methods of treating or preventing tuberculosis in a subject by administering a composition of the present disclosure to the subject.
Claims35
A composition comprising:
- a particle, an antigen, and a modulator encapsulated within the particle,
- wherein the modulator is selected from the group consisting of an agonist, an activator of the immune system, or combinations thereof, and
- wherein the antigen is operable to elicit an immune response in a subject against Mycobacterium tuberculosis.
A method of treating or preventing tuberculosis in a subject, said method comprising:
- administering a composition to a subject, wherein the composition comprises:
- a particle, an antigen, and a modulator encapsulated within the particle,
- wherein the modulator is selected from the group consisting of an agonist, an activator of the immune system, or combinations thereof, and
- wherein the antigen is operable to elicit an immune response in a subject against Mycobacterium tuberculosis.
Dependencies are inferred from the claim text.