US 2026/0306601 A1 · COMPOSITIONS AND METHODS FOR GENERATING IMMUNITY TO BACTERIAL INFECTION

Abstract

The present disclosure relates, in part, to a polypeptide of formula (I), or a salt or solvate thereof, and a vaccine composition thereof further comprising at least one pharmaceutically acceptable excipient. The present disclosure further relates to isolated mRNA and/or isolated polynucleotides encoding the polypeptide of formula (I), vectors and/or LNPs comprising the same, and pharmaceutical compositions thereof. The present disclosure further relates to methods of treating, preventing, and/or ameliorating a bacterial infection, and/or generating immunity to infection by one or more pathogenic bacteria, in a subject in need thereof, the method comprising administering to the subject at least one composition of the present disclosure. In certain embodiments, the bacterial infection is a urinary tract infection, sepsis (e.g., neonatal sepsis), or pneumonia.

Claims37

Dependent claims

A 1 tide comprising formula (I), or a salt or solvate thereof:

wherein:
each occurrence of B1, B2, B3, L1, L2, L3, L4, L5, L6, T1, T2, and T3 can be present or absent;
each occurrence of B1, B2, and B3, if present, independently comprise an immunogenic fragment of a bacterial surface protein;
each occurrence of T1, T2, and T3, if present, independently comprise an immunogenic fragment of an iron receptor protein,
wherein at least two of T1, T2, and T3 are present or at least one of T1, T2 and T3 is present and n is at least 2;
each occurrence of L1, L2, L3, L4, L5, and L6, if present, independently comprise a polypeptide of 1-10 amino acids,
wherein at least one of L1, L2, L3, L4, L5, and L6 is present, and
wherein each occurrence of B1, B2, B3, T1, T2, and T3 are separated from one another by at least one of L1, L2, L3, L4, L5, and L6;
and
n is an integer selected from the group consisting of 1, 2, 3, 4, and 5.

7 more elements

Dependencies are inferred from the claim text.

Compositions and methods for generating immunity to bacterial infection

Life of this patent

Compositions and methods for generating immunity to bacterial infection

Life of this patent

Abstract

Claims37