Timp3-derived teipp neoantigens and uses thereof
OwnerSjoerd Henricus VAN DER BURG, Thorbald VAN HALL +1inventors
InventorsSjoerd Henricus VAN DER BURG, Thorbald VAN HALL, Koen Abraham MARIJT
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Abstract
Novel nucleic acid sequences, vectors, modified cells, binding agents, peptides and pharmaceutical compositions are provided herein that are useful as a medicament, for example in the prevention or treatment of cancer or viral infections associated with impaired HLA class I antigen presentation. Corresponding methods and uses are also provided herein.
Claims38
A vaccine comprising:
- (a) a peptide comprising the amino acid sequence of SEQ ID NO:
- 1, or a nucleic acid encoding the peptide;
- and
- (b) a pharmaceutically acceptable excipient, adjuvant, diluent and/or carrier.
The vaccine of any preceding claim, wherein the peptide is conjugated to an immune stimulatory compound, optionally wherein the immune stimulatory compound comprises a TLR ligand.
A complex comprising:
- a) a peptide comprising the amino acid sequence of SEQ ID NO:
- 1, and
- b) a binding agent that specifically binds to a peptide comprising the amino acid sequence of SEQ ID NO:
- 1;
- optionally wherein the binding agent is an HLA-A*02 molecule, further optionally wherein the binding agent is an HLA-A*02:01 molecule.
An isolated nucleic acid composition that encodes a TIMP3 antigen-specific binding protein having a TCR α chain variable (Na) domain and a TCR β chain variable (Vβ) domain, the composition comprising:
- a nucleic acid sequence that encodes a TCR Vα domain comprising a CDR3 amino acid sequence;
- and a nucleic acid sequence that encodes a TCR Vβ domain comprising a CDR3 amino acid sequence;
- wherein the CDR3 sequences together specifically bind to a peptide comprising the amino acid sequence of SEQ ID NO:
- 1.
An isolated nucleic acid encoding a chimeric antigen receptor protein comprising a target binding moiety that specifically binds to a peptide comprising the amino acid sequence of SEQ ID NO:
- 1.
A pharmaceutical composition comprising a nucleic acid, a nucleic acid composition, a complex, or a cell according to any preceding claim, and a pharmaceutically acceptable excipient, adjuvant, diluent and/or carrier.
Dependencies are inferred from the claim text.