Cannabinoid-based formulation
OwnerCharles MORGAN, Melissa STURGESS +1inventors
InventorsCharles MORGAN, Melissa STURGESS, Nicholas CLARKSON
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Abstract
The invention relates to cannabinoid-based formulations, and particularly, although not exclusively, to methods for preparing cannabinoid-based formulations, and to the formulations per se, and their use in therapy. The invention is especially concerned with cannabidiol (CBD)-based formulations, their manufacture and uses, for treating various conditions.
Claims40
A method of producing a cannabinoid-based formulation comprising a cannabinoid and substantially lacking tetrahydrocannabinol (THC), the method comprising combining:
- (i) one or more cannabinoid;
- and (ii) a plurality of terpenes, to produce a cannabinoid-based formulation, wherein the formulation substantially lacks THC.
The method according to any preceding claim, wherein the formulation comprises no detectable THC using reasonable means of analysis.
The method according to any preceding claim, wherein the one, two or three cannabinoids selected from a group of cannabinoids consisting of:
- cannabidiol (CBD);
- cannabichromene (CBC);
- cannabigerol (CBG);
- and cannabigerol monomethyl ether (CBGM).
The method according to any preceding claim, wherein the one or more cannabinoid comprises CBD.
The method according to any preceding claim, wherein the one or more cannabinoid comprises an isolate of cannabidiol (CBD).
The method according to any preceding claim, wherein the formulation does not comprise CBC, CBG, or CBGM.
The method according to any preceding claim, wherein the one or more cannabinoid is prepared using solvent extraction or enzyme digestion of plant material, preferably inflorescence and/or leaves of Cannabis sativa.
The method according to any preceding claim, wherein the purity of the one or more cannabinoid is at least 97%, at least 98% or at least 99%, or about 98-100%.
The method according to any preceding claim, wherein the concentration of the one or more cannabinoid, preferably CBD, in the cannabinoid-based formulation is at least 2% (w/v), at least 3% (w/v) or at least 4% (w/v).
The method according to any preceding claim, wherein the concentration of the one or more cannabinoid, preferably CBD, in the cannabinoid-based formulation is at least 5% (w/v), at least 6% (w/v) or at least 7% (w/v).
The method according to any preceding claim, wherein the concentration of the one or more cannabinoid, preferably CBD, in the cannabinoid-based formulation is at least 8% (w/v), at least 9% (w/v) or at least 10% (w/v).
The method according to any preceding claim, wherein the concentration of the one or more cannabinoid, preferably CBD, in the cannabinoid-based formulation between 7 and 13% (w/v), or between 8 and 12% (w/v).
The method according to any preceding claim, wherein the concentration of the one or more cannabinoid, preferably CBD, in the cannabinoid-based formulation between 9 and 11% (w/v).
The method according to any preceding claim, wherein the plurality of terpenes is prepared by first steam distillation from the appropriate species of plant to produce an essential oil, and then the resulting essential oil is then purified by chromatography, preferably flash chromatography, to separate the individual terpene components at the required purity.
The method according to any preceding claim, wherein the purity of the plurality of terpenes is at least 90%, at least 92% or at least 95% of total terpenes.
The method according to any preceding claim, wherein the plurality of terpenes is selected from a group of terpenes consisting of:
- Alpha-Pinene, Beta-Pinene, Limonene, Cis-Ocimene, Beta-Myrcene, Terpinolene, Linalool, Alpha-Phellandrene, Gamma-Terpinene, Alpha-Terpineol, Borneol, Camphene, Eucalyptol, Fenchol, Beta-Caryophyllene, Alpha-Humulene, Trans Beta Farnasene, Bisabolol, Caryophyllene Oxide, Nerolidol, Guaiol, Cedrol, Beta-Eudesmol, Santalene, Bergomotene, Alpha-Guaiene, Geraniol and Bisbolene.
The method according to any preceding claim, wherein the plurality of terpenes comprises:
- (i) at least three terpenes selected from a group of terpenes consisting of:
- Alpha-Pinene, Beta-Pinene, Limonene, Cis-Ocimene, Beta-Myrcene, Terpinolene, Linalool, Alpha-Phellandrene, Gamma-Terpinene, Alpha-Terpineol, Borneol, Camphene, Eucalyptol, Fenchol, Beta-Caryophyllene, Alpha-Humulene, Trans Beta Farnasene, Bisabolol, Caryophyllene Oxide, Nerolidol, Guaiol, Cedrol, Beta-Eudesmol, Santalene, Bergomotene, Alpha-Guaiene, Geraniol and Bisbolene;
- (ii) at least four terpenes selected from a group of terpenes consisting of:
- Alpha-Pinene, Beta-Pinene, Limonene, Cis-Ocimene, Beta-Myrcene, Terpinolene, Linalool, Alpha-Phellandrene, Gamma-Terpinene, Alpha-Terpineol, Borneol, Camphene, Eucalyptol, Fenchol, Beta-Caryophyllene, Alpha-Humulene, Trans Beta Farnasene, Bisabolol, Caryophyllene Oxide, Nerolidol, Guaiol, Cedrol, Beta-Eudesmol, Santalene, Bergomotene, Alpha-Guaiene, Geraniol and Bisbolene;
- (iii) at least five terpenes selected from a group of terpenes consisting of:
- Alpha-Pinene, Beta-Pinene, Limonene, Cis-Ocimene, Beta-Myrcene, Terpinolene, Linalool, Alpha-Phellandrene, Gamma-Terpinene, Alpha-Terpineol, Borneol, Camphene, Eucalyptol, Fenchol, Beta-Caryophyllene, Alpha-Humulene, Trans Beta Farnasene, Bisabolol, Caryophyllene Oxide, Nerolidol, Guaiol, Cedrol, Beta-Eudesmol, Santalene, Bergomotene, Alpha-Guaiene, Geraniol and Bisbolene;
- (iv) at least six terpenes selected from a group of terpenes consisting of:
- Alpha-Pinene, Beta-Pinene, Limonene, Cis-Ocimene, Beta-Myrcene, Terpinolene, Linalool, Alpha-Phellandrene, Gamma-Terpinene, Alpha-Terpineol, Borneol, Camphene, Eucalyptol, Fenchol, Beta-Caryophyllene, Alpha-Humulene, Trans Beta Farnasene, Bisabolol, Caryophyllene Oxide, Nerolidol, Guaiol, Cedrol, Beta-Eudesmol, Santalene, Bergomotene, Alpha-Guaiene, Geraniol and Bisbolene;
- (v) at least seven terpenes selected from a group of terpenes consisting of:
- Alpha-Pinene, Beta-Pinene, Limonene, Cis-Ocimene, Beta-Myrcene, Terpinolene, Linalool, Alpha-Phellandrene, Gamma-Terpinene, Alpha-Terpineol, Borneol, Camphene, Eucalyptol, Fenchol, Beta-Caryophyllene, Alpha-Humulene, Trans Beta Farnasene, Bisabolol, Caryophyllene Oxide, Nerolidol, Guaiol, Cedrol, Beta-Eudesmol, Santalene, Bergomotene, Alpha-Guaiene, Geraniol and Bisbolene.
- (vi) at least eight terpenes selected from a group of terpenes consisting of:
- Alpha-Pinene, Beta-Pinene, Limonene, Cis-Ocimene, Beta-Myrcene, Terpinolene, Linalool, Alpha-Phellandrene, Gamma-Terpinene, Alpha-Terpineol, Borneol, Camphene, Eucalyptol, Fenchol, Beta-Caryophyllene, Alpha-Humulene, Trans Beta Farnasene, Bisabolol, Caryophyllene Oxide, Nerolidol, Guaiol, Cedrol, Beta-Eudesmol, Santalene, Bergomotene, Alpha-Guaiene, Geraniol and Bisbolene;
- (vii) at least nine terpenes selected from a group of terpenes consisting of:
- Alpha-Pinene, Beta-Pinene, Limonene, Cis-Ocimene, Beta-Myrcene, Terpinolene, Linalool, Alpha-Phellandrene, Gamma-Terpinene, Alpha-Terpineol, Borneol, Camphene, Eucalyptol, Fenchol, Beta-Caryophyllene, Alpha-Humulene, Trans Beta Farnasene, Bisabolol, Caryophyllene Oxide, Nerolidol, Guaiol, Cedrol, Beta-Eudesmol, Santalene, Bergomotene, Alpha-Guaiene, Geraniol and Bisbolene;
- (viii) at least ten terpenes selected from a group of terpenes consisting of:
- Alpha-Pinene, Beta-Pinene, Limonene, Cis-Ocimene, Beta-Myrcene, Terpinolene, Linalool, Alpha-Phellandrene, Gamma-Terpinene, Alpha-Terpineol, Borneol, Camphene, Eucalyptol, Fenchol, Beta-Caryophyllene, Alpha-Humulene, Trans Beta Farnasene, Bisabolol, Caryophyllene Oxide, Nerolidol, Guaiol, Cedrol, Beta-Eudesmol, Santalene, Bergomotene, Alpha-Guaiene, Geraniol and Bisbolene.
- (ix) at least eleven terpenes selected from a group of terpenes consisting of:
- Alpha-Pinene, Beta-Pinene, Limonene, Cis-Ocimene, Beta-Myrcene, Terpinolene, Linalool, Alpha-Phellandrene, Gamma-Terpinene, Alpha-Terpineol, Borneol, Camphene, Eucalyptol, Fenchol, Beta-Caryophyllene, Alpha-Humulene, Trans Beta Farnasene, Bisabolol, Caryophyllene Oxide, Nerolidol, Guaiol, Cedrol, Beta-Eudesmol, Santalene, Bergomotene, Alpha-Guaiene, Geraniol and Bisbolene;
- (x) at least twelve terpenes selected from a group of terpenes consisting of:
- Alpha-Pinene, Beta-Pinene, Limonene, Cis-Ocimene, Beta-Myrcene, Terpinolene, Linalool, Alpha-Phellandrene, Gamma-Terpinene, Alpha-Terpineol, Borneol, Camphene, Eucalyptol, Fenchol, Beta-Caryophyllene, Alpha-Humulene, Trans Beta Farnasene, Bisabolol, Caryophyllene Oxide, Nerolidol, Guaiol, Cedrol, Beta-Eudesmol, Santalene, Bergomotene, Alpha-Guaiene, Geraniol and Bisbolene;
- (xi) at least thirteen terpenes selected from a group of terpenes consisting of:
- Alpha-Pinene, Beta-Pinene, Limonene, Cis-Ocimene, Beta-Myrcene, Terpinolene, Linalool, Alpha-Phellandrene, Gamma-Terpinene, Alpha-Terpineol, Borneol, Camphene, Eucalyptol, Fenchol, Beta-Caryophyllene, Alpha-Humulene, Trans Beta Farnasene, Bisabolol, Caryophyllene Oxide, Nerolidol, Guaiol, Cedrol, Beta-Eudesmol, Santalene, Bergomotene, Alpha-Guaiene, Geraniol and Bisbolene;
- (xii) at least fourteen terpenes selected from a group of terpenes consisting of:
- Alpha-Pinene, Beta-Pinene, Limonene, Cis-Ocimene, Beta-Myrcene, Terpinolene, Linalool, Alpha-Phellandrene, Gamma-Terpinene, Alpha-Terpineol, Borneol, Camphene, Eucalyptol, Fenchol, Beta-Caryophyllene, Alpha-Humulene, Trans Beta Farnasene, Bisabolol, Caryophyllene Oxide, Nerolidol, Guaiol, Cedrol, Beta-Eudesmol, Santalene, Bergomotene, Alpha-Guaiene, Geraniol and Bisbolene;
- and/or
- (xiii) at least fifteen terpenes selected from a group of terpenes consisting of:
- Alpha-Pinene, Beta-Pinene, Limonene, Cis-Ocimene, Beta-Myrcene, Terpinolene, Linalool, Alpha-Phellandrene, Gamma-Terpinene, Alpha-Terpineol, Borneol, Camphene, Eucalyptol, Fenchol, Beta-Caryophyllene, Alpha-Humulene, Trans Beta Farnasene, Bisabolol, Caryophyllene Oxide, Nerolidol, Guaiol, Cedrol, Beta-Eudesmol, Santalene, Bergomotene, Alpha-Guaiene, Geraniol and Bisbolene.
The method according to any preceding claim, wherein the plurality of terpenes comprises at least two, three, four or five terpenes selected from a group of terpenes consisting of:
- Alpha-Pinene, Beta-Pinene, Limonene, Cis-Ocimene, Beta-Caryophyllene, Alpha-Humulene, Beta-Myrcene, Terpinolene, Trans Beta Farnasene, Linalool, Bisabolol, Alpha-Phellandrene, Gamma-Terpinene, Geraniol and Alpha-Terpineol.
The method according to any preceding claim, wherein the plurality of terpenes comprises at least six, seven or eight terpenes selected from a group of terpenes consisting of:
- Alpha-Pinene, Beta-Pinene, Limonene, Cis-Ocimene, Beta-Caryophyllene, Alpha-Humulene, Beta-Myrcene, Terpinolene, Trans Beta Farnasene, Linalool, Bisabolol, Alpha-Phellandrene, Gamma-Terpinene, Geraniol and Alpha-Terpineol.
The method according to any preceding claim, wherein the plurality of terpenes comprises at least nine, ten or eleven terpenes selected from a group of terpenes consisting of:
- Alpha-Pinene, Beta-Pinene, Limonene, Cis-Ocimene, Beta-Caryophyllene, Alpha-Humulene, Beta-Myrcene, Terpinolene, Trans Beta Farnasene, Linalool, Bisabolol, Alpha-Phellandrene, Gamma-Terpinene, Geraniol and Alpha-Terpineol.
The method according to any preceding claim, wherein the plurality of terpenes comprises at least twelve, thirteen, fourteen or fifteen terpenes selected from a group of terpenes consisting of:
- Alpha-Pinene, Beta-Pinene, Limonene, Cis-Ocimene, Beta-Caryophyllene, Alpha-Humulene, Beta-Myrcene, Terpinolene, Trans Beta Farnasene, Linalool, Bisabolol, Alpha-Phellandrene, Gamma-Terpinene, Geraniol and Alpha-Terpineol.
The method according to any preceding claim, wherein the method comprises combining the cannabinoid and plurality of terpenes with a pharmaceutically acceptable excipient or carrier.
The method according to any preceding claim, wherein the cannabinoid-based formulation is in a liquid form, and optionally comprises a tincture.
The method according to any preceding claim, wherein the formulation is administrable by sublabial, buccal, sublingual, or oropharyngeal administration delivery.
Dependencies are inferred from the claim text.