Methods and materials for treating cancer
AssigneesMayo Foundation for Medical Education and Research, Vyriad, Inc.
InventorsAutumn J. Schulze, Stephen J. Russell, Kyla A. Boyd, Miguel A. Munoz Alia, Luke Russel
Life of this patent
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Abstract
This document provides methods and materials involved in treating cancer. For example, methods and materials for using (a) an oncolytic virus (or infectious nucleic acid coding for an oncolytic virus) such as a picornavirus and (b) ribonucleic acid (RNA) including an internal ribosome entry site (IRES) and a nucleic acid sequence encoding an immune antagonist polypeptide (e.g., a viral immune antagonist polypeptide) to treat a mammal (e.g., a human) having cancer (e.g., cancers that exhibit little or no response to treatment with an oncolytic virus (or nucleic acid coding for an oncolytic virus) alone) are provided.
Claims26
A method for treating a mammal having cancer, wherein said method comprises:
- (a) administering infectious nucleic acid encoding a picornavirus to said mammal;
- and
- (b) administering ribonucleic acid (RNA) comprising an internal ribosome entry site (IRES) and a nucleic acid sequence encoding an immune antagonist polypeptide to said mammal.
7-8. (canceled)
10-12. (canceled)
(canceled)
A method for treating a mammal having cancer, wherein said method comprises:
- (a) administering a picornavirus to said mammal;
- and
- (b) administering ribonucleic acid (RNA) comprising an internal ribosome entry site (IRES) and a nucleic acid sequence encoding an immune antagonist polypeptide to said mammal.
23-24. (canceled)
26-28. (canceled)
32-59. (canceled)
Dependencies are inferred from the claim text.