Novel phosphoantigen prodrug compound and use thereof
OwnerYoucef MEHELLOU, Benjamin WILLCOXinventors
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Abstract
The invention relates to a novel phosphoantigen (PAg) prodrug compound which provides for a potent activation of therapeutically active γδ T cells. The PAg prodrug compound of the invention can be used for the preparation of therapeutically active γδ T cells as well as in the immunotherapy of different diseases, and in particular different types of cancer. The invention further relates to a method for expanding γδ T-cells ex vivo which makes use of the PAg pro-drug compound of the invention. Also provided are γδ T-cells which have been expanded with the PAg prodrug compound of the invention and pharmaceutical compositions comprising such expanded cells and/or the PAg prodrug compound of the invention.
Claims22
A compound according to General Formula (I) including all tautomers thereof:
- wherein R1 represents an amino acid ester radical according to General Formula (II):
- wherein R3 represents H, or a saturated or unsaturated and optionally substituted hydrocarbon chain;
- R4 represents a saturated or unsaturated and optionally substituted hydrocarbon chain;
- and wherein both R1 are identical;
- and
- R2 represents an optionally substituted C2-20 alkyl, C4-20 alkenyl or C2-20 alcohol radical;
- and
- each of X and Y independently represent H or halo;
- or a salt thereof, and
- wherein R1 is an amino acid ester radical according to General Formula (II) derived from alanine (R3=—CH3), leucine (R3=—CH2CH(CH3)2), isoleucine (R3=—CH(CH3)CH2CH3) or methionine (R3=—CH2CH2SCH3), most preferably R1 is an amino acid ester radical according to General Formula (II) derived from alanine (R3=—CH3);
- and
- wherein R2 is a radical according to Formula (III) or Formula (IV), wherein R5 in Formula (IV) is selected from OH, OR6, SH, SR6, NH2 or NHR6, and wherein R6 represents C1-4 alkyl:
- preferably, wherein R2 is a radical according to Formula (IV).
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Dependencies are inferred from the claim text.