Method for synthesizing zeolite nanoparticles in a saline phosphate buffer and associated nanoparticles, suspensions, pharmaceutical composition and uses

A method for synthesising nanoparticles consisting of or comprising at least one zeolite nanocrystal according to which:

• a first composition/solution 1 containing an aluminium source and a source of an ion of an alkali metal M, in particular Na, is prepared;
• a second composition/solution 2 comprising a silicon source and a source of an ion of an alkali metal M in particular Na, is prepared, said compositions/solutions 1 and 2 being free of any organic structuring agent;
• the compositions/solutions 1 and 2 are mixed and the mixture is left under stirring,
• the mixture is crystallised at a temperature greater than or equal to 50° C.;
• and
• said nanoparticles thus formed are optionally separated,
• wherein said first composition/solution 1 and said second composition/solution 2 are each consisting of said source and of an aqueous buffer consisting of water and of 137 mM/L of NaCl, 2.7 mM/L of KCl, 10 mM/L of Na2HPO4, 1.76 mM/L of KH2PO4 and having a pH equal to 7.2 (PBS) and in that said mixture of said compositions/suspensions 1 and 2 has the following molar composition (I):
• X1M2O:YAl2O3:10SiO2:Z PBS (I)
• wherein 2.8≤X1≤8.8,
• 0.3
• ≤
• Y
• ≤
• 1.5
• ,
• 40
• ≤
• Z
• ≤
• 30
• ⁢
• 0
• .