Prmt inhibitor compounds and the uses thereof

A compound having the formula (III), wherein the compound has the formula (III):

• or a pharmaceutically acceptable salt thereof,
• wherein:
• each n is independently an integer from 1-12;
• and
• Y and Z are either NH or O, and
• R1 is an acyl, alkyl, alkenyl, alkynyl, heteroalkyl, heteroalkenyl, heteroalkynyl, cycloalkyl, heterocyloalkyl, cycloalkenyl, heterocycloakenyl, heterocyclyl, or an optionally substituted aryl, arylalkyl, or arylalkenyl, and
• R2 is an H or an acyl, alkyl, alkenyl, alkynyl, heteroalkyl, heteroalkenyl, heteroalkynyl, cycloalkyl, heterocyloalkyl, cycloalkenyl, heterocycloakenyl, heterocyclyl, or an optionally substituted aryl, arylalkyl, arylalkenyl or aryalkynyl, and
• R3 is an acyl, alkyl, alkenyl, alkynyl, heteroalkyl, heteroalkenyl, heteroalkynyl, cycloalkyl, heterocyloalkyl, cycloalkenyl, heterocycloakenyl, heterocyclyl, or an optionally substituted aryl, arylalkyl, or arylalkenyl.

A compound of the formula:

• or a pharmaceutically acceptable salt thereof, wherein:
• X is a N or S,
• X′ is a NH, S or O,
• n is an integer from 1-12;
• and
• Y is NRp or O, wherein Rp is H or a protecting group, and
• Z1 is N or CH, and
• Z2 is O or CH2, and
• each R1 is, independently, an acyl, alkyl, alkenyl, alkynyl, heteroalkyl, heteroalkenyl, heteroalkynyl, cycloalkyl, heterocyloalkyl, cycloalkenyl, heterocycloakenyl, heterocyclyl, or an optionally substituted aryl, arylalkyl, or arylalkenyl, and
• R2 is an H or an acyl, alkyl, alkenyl, alkynyl, heteroalkyl, heteroalkenyl, heteroalkynyl, cycloalkyl, heterocyloalkyl, cycloalkenyl, heterocycloakenyl, heterocyclyl, or an optionally substituted aryl, arylalkyl, arylalkenyl or aryalkynyl.