Compounds and compositions for treating glucose hypometabolic disorders

A compound of Formula (A):

• or a pharmaceutically acceptable salt or solvate thereof, wherein
• R1 is a polyol, amino acid, or a derivative thereof;
• X is a covalent linker selected from the group consisting of —O—C(O)—, —C(O)—O—, —C(O)—NH—, —NH—C(O)—, —C(O)—S—, —S—C(O)—, —O—C(O)—O—, —O—C(O)—NH— or —NH—C(O)—O—, —O—P(O2)—O—, —O−SO2—O—, —C═N—, —C═N—NH—, —O—, —NH—, —S—, and —S—S—;
• R2 is a ketone body moiety selected from β-hydroxybutyryl, acetoacetyl, or a derivative thereof;
• and
• n is an integer from 1 to 50, wherein n represents the total number of ketone body moieties attached to R1, and wherein n can be less than or equal to the total number of available attachment sites on R1.