Pyrido[4,3-d]pyrimidine compounds

1:

• A compound of Formula (I):
• or a pharmaceutically acceptable salt thereof, wherein:
• R1 is C3-C10 cycloalkyl or 4-12 membered heterocycloalkyl comprising one, two or three heteroatoms selected from the group consisting of N, O, and S, wherein said C3-C10 cycloalkyl or said 4-12 membered heterocycloalkyl is substituted with one or two substituents independently selected from the group consisting of C1-C3 alkylidenyl and C1-C3 haloalkylidenyl, wherein said C3-C10 cycloalkyl or said 4-12 membered heterocycloalkyl is further optionally substituted with one, two or three substituents independently selected from the group consisting of —OH, —CN, halogen, C1-C3 alkyl, C1-C3 alkoxy, —OC(O)NH2, —OC(O)NHCH3, —OC(O)N(CH3)2, and —C(O)O(C1-C3 alkyl), wherein the C1-C3 alkyl or the C1-C3 alkoxy is each optionally substituted with one, two or three substituents independently selected from the group consisting of —OH, —OCH3, methyl, and halogen;
• R2 is H or is selected from the group consisting of —(C1-C6 alkylene)-OH, —(C1-C6 alkylene)-CN, —(C1-C6 alkylene)-SH, —(C1-C3 alkylene)-S—(C1-C3 alkyl), —(C1-C3 alkylene)-(S═O)—(C1-C3 alkyl), —(C1-C3 alkylene)-(SO2)—(C1-C3 alkyl), C1-C6 alkyl, C3-C6 cycloalkyl, C1-C6 fluoroalkyl, C3-C6 fluorocycloalkyl, and C1-C6 alkoxy, each optionally substituted with one, two or three substituents independently selected from the group consisting of —OH, —CN, —NH2, —NH(C1-C3 alkyl), —N(C1-C3 alkyl)2, —SH, —(C1-C4 alkylene)-CN, —(C1-C4 alkylene)-OH, halogen, C1-C3 alkyl, C3-C6 cycloalkyl, C1-C3 fluoroalkyl, and C1-C3 alkoxy;
• R3 a naphthyl optionally substituted with one to four substituents independently selected from the group consisting of —OH, halogen, —CN, C1-C3 alkyl, C1-C3 alkoxy, C1-C3 fluoroalkyl, and C2-C3 alkynyl;
• R4 is H, halogen, C1-C3 alkyl, C1-C3 alkoxy, or C1-C3 fluoroalkyl;
• R5 is H, —OH, halogen, —NH2, CN, or selected from the group consisting of —(C1-C6 alkylene)-OH, —(C1-C6 alkylene)-CN, —(C1-C6 alkylene)-SH, —(C1-C3 alkylene)-S—(C1-C3 alkyl), —(C1-C3 alkylene)-(S═O)—(C1-C3 alkyl), —(C1-C3 alkylene)-(SO2)—(C1-C3 alkyl), C1-C6 alkyl, C3-C6 cycloalkyl, C1-C6 fluoroalkyl, C3-C6 fluorocycloalkyl, and C1-C6 alkoxy each is optionally substituted with one, two or three substituents independently selected from the group consisting of —OH, —CN, —NH2, —SH, —(C1-C4 alkylene)-CN, halogen, C1-C3 alkyl, C3-C6 cycloalkyl, C1-C3 fluoroalkyl, and C1-C3 alkoxy;
• or alternatively, R5 and the carbon that R5 is attached to, and R2 and the nitrogen that R2 is attached to together to form a 4-8 membered heterocycloalkyl comprising one, two or three heteroatoms selected from the group consisting of N, O, and S, or heteroatom-containing groups selected from the group consisting of N(C1-C6 alkyl), —(S═O)—, and —(SO2)—, wherein said 4-8 membered heterocycloalkyl is optionally substituted with one, two or three substituent groups selected from the group consisting of —OH, —OCH3, —CN, halogen, C1-C3 alkyl, —(C1-C6 alkylene)-CN, and —(C1-C6 alkylene)-OH;
• R6 at each occurrence is independently H, —OH, halogen, CN, or selected from the group consisting of —(C1-C6 alkylene)-OH, —(C1-C6 alkylene)-CN, C1-C6 alkyl, C3-C6 cycloalkyl, C1-C6 fluoroalkyl, C3-C6 fluorocycloalkyl, and C1-C6 alkoxy, each optionally substituted with one, two or three substituents independently selected from the group consisting of —OH, —CN, —(C1-C4 alkylene)-CN, halogen, C1-C3 alkyl, C3-C6 cycloalkyl, C1-C3 fluoroalkyl, and C1-C3 alkoxy;
• L is a linker comprising one, two or three members independently selected from the group consisting of —O—, —S—, —NR7—, and —CR8R9;
• R7, R8, and R9 are each independently H or C1-C3 alkyl;
• X is O, N, or S;
• l is 1 or 2;
• and
• x is 0, 1, or 2,
• wherein the compound of Formula (I) is not the compound selected from the group consisting of: