Methods and pharmaceutical compositions comprising d1-like dopamine receptor agonist for the treatment of autosomal dominant polycystic kidney disease

Abstract

Autosomal dominant polycystic kidney disease (ADPKD) is a hereditary disease affecting 1 in 1,000 to 1 in 2,500 individuals worldwide. The inventor's study performed in 6 patients with ADPKD supports the hypothesis that the stimulation of the dopaminergic system, in particular D1-like family of dopamine receptors, may improve endothelial function by restoring cilia length and mechanotransductory capacity. The inventors carefully assess whether the deficiency in endothelial polycystin-1 and cilia promotes or potentiates both cardiovascular and renal alterations, to explore the mechanisms involved, and to propose and test new pharmacological approaches, in particular targeting the dopaminergic system, to prevent complications of ADPKD. The present invention relates to a method of treating autosomal dominant polycystic kidney disease (ADPKD) in a subject in need thereof comprising a step of administering said subject with a therapeutically effective amount of a D1-like family of dopamine receptors agonist through a continuous systemic delivery.

Dependencies are inferred from the claim text.