Liquid and solid compositions of imipridone derivatives

Abstract

A liquid pharmaceutical composition comprising an aqueous solvent, nicotinamide and at least one imipridone derivative of formula (I). A process for manufacturing said liquid pharmaceutical composition, wherein the process comprises the steps of (a) Dissolving nicotinamide in an aqueous solvent, preferably water; (b) Adding at least one pH modifier and at least one imipridone derivative to the solution obtained in step (a); and (c) Optionally sterilizing the solution obtained in step (b). A 1:1 imipridone derivative nicotinamide complex or cocrystal, wherein the imipridone derivative is of formula (I). Said compositions for use in the treatment of cancer.

Dependencies are inferred from the claim text.