Substituted nucleoside analogs as prmt5 inhibitors
AssigneeLupin Limited
InventorsPrathap Sreedharan NAIR, Ganesh Bhausaheb GUDADE, Shankar Bhaskar BHAGWAT, Amol Maruti YADAV, Chaitanya Prabhakar KULKARNI, Milind Dattatraya SINDKHEDKAR, Venkata P. PALLE, Rajender Kumar KAMBOJ
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Abstract
The invention relates to substituted nucleoside analogues of formula (1), pharmaceutically acceptable salts thereof and pharmaceutical compositions for treating diseases, disorders or conditions associated with the overexpression of PRMT5 enzyme. The invention also relates to methods of treating diseases, disorders or conditions associated with the overexpression of PRMT5 enzyme.
Claims9
A compound of formula (III), its stereoisomer, or its pharmaceutically acceptable salt,
- wherein,
- L1 is —CH2— or O;
- ring A is
- Hy is selected from formula (a-1), (b-1) and (d-1),
- R is methyl;
- R3 is independently selected at each occurrence from halogen, substituted or unsubstituted alkyl and —NR7R8;
- R7 and R8 are independently selected from hydrogen;
- R10 is hydrogen;
- ‘m’ is 1;
- ‘n’ is an integer ranging from 0 to 3, both inclusive;
- with a proviso that the compound is not (1S,2R,5R)-3-(2-(2-Amino-3-chloro-5-fluoroquinolin-7-yl)ethyl)-5-(2-amino-4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclopent-3-ene-1,2-diol.
Dependencies are inferred from the claim text.