Inhaled statins as bronchodilators to improve lung function in respiratory diseases
AssigneesThe Regents of the University of California, Beth Israel Deaconess Medical Center, Inc.
InventorsAmir A. Zeki, Chandra C. Ghosh, Ramaswamy Krishnan
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Abstract
The present disclosure relates to methods for relaxing airway smooth muscle tissue, alleviating or preventing bronchospasm, and treating lung diseases by administering an HMG-CoA reductase inhibitor (statin) directly to lung tissue by inhalation. The disclosure also relates to formulations and compositions useful for the practice of methods of the disclosure.
Claims17
-131. (canceled)
A method of treating chronic obstructive pulmonary disease (COPD) in a subject in need thereof, comprising administering to the subject by inhalation a therapeutically effective amount of a statin selected from the group consisting of simvastatin and pitavastatin, or an isomer, enantiomer, or diastereomer thereof.
Dependencies are inferred from the claim text.