Compositions and methods for treating cancer by targeting bach1

Abstract

The present disclosure relates to compositions and methods for treating cancers, such as breast cancer, or enhancing a therapeutic efficacy of an anti-cancer agent. The methods include administering a therapeutically effective amount of a transcription factor BTB and CNC Homology 1 (BACH1) inhibitor to the subject. The methods also further include administering a therapeutically effective amount of an anti-cancer agent. The compositions can include a therapeutically effective amount of a BACH1 inhibitor, or a therapeutically effective amount of a BACH1 inhibitor and a therapeutically effective amount of an anti-cancer agent. Finally, the present disclosure also relates to methods of treating cancer in a subject, including detecting a level of expression and/or activity of BACH1 and/or of an immune checkpoint protein in the subject's cancer tumor; and administering a therapeutically effective amount of the BACH1 inhibitor and an inhibitor of the immune checkpoint protein to the subject.

Dependencies are inferred from the claim text.