Formulations containing tryptamine derivatives and uses thereof
AssigneePsilera Inc.
InventorsJacqueline L. Salm, Christopher G. Witowski
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Abstract
Pharmaceutical compositions that comprise therapeutically effective amounts of a psychedelics may be used to treat, to manage or to prevent neurological, psychiatric and other diseases and disorders. Through delivery of these compounds, one may safely and effectively allow subjects to address the undesirable symptoms of these diseases and disorders and/or the diseases and disorders themselves.
Claims71
A pharmaceutical composition comprising a therapeutically effective amount of a compound that is defined by Structure (1) or a pharmaceutically acceptable salt, a solvate, metabolite, or a prodrug thereof:
- wherein R1 is selected from the group consisting of Br, F, Cl, I, CF3 and H;
- R2 is H or CH3;
- R3 and R4 are each independently selected from the group consisting of CH3, C2H5, (H3C)2CH, H2C═CH—CH2 and H;
- R5 is selected from the group consisting of OCOCH3, OH, OCH3, O-phosphate, O-polyethylene glycol (PEG), O-succinate, O-hemi-succinate, O-sulfate, fumarate, tartrate, maleate, sugar, amino acid, and CH2SO2NHCH3;
- and
- wherein when R1 is H then R5 is CH2SO2NHCH3, CH2NHSO2CH3, or CH2NHCON(CH2CH3)2.
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Dependencies are inferred from the claim text.