Methods for using bacteria and host/microbiota-derived metabolites for diagnosis and treatment of endometriosis
AssigneeBaylor College of Medicine
InventorRamakrishna Kommagani
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Abstract
Compositions and methods involving bacteria and metabolites derived from the microbiotaare provided herein in certain aspects to reduced endometriosis. This includes therapeutic compositions comprising the bacteria and/or metabolites, as well as methods of administering the bacteria and/or metabolites to an individual in need thereof.
Claims43
A method of treating endometriosis in an individual, the method comprising administering to the individual an effective amount of at least one indole metabolite.
A method of treating endometriosis in an individual, the method comprising administering to the individual an effective amount of at least one metabolite of Table 1.
A therapeutic composition comprising 4-hydroxyindole (4HI) and indole-4-carbaldehyde.
A method for detecting endometriosis in an individual, the method comprising measuring one or more metabolites from Table 1 and/or at least one bacteria from Table 2 in a biological sample from the individual.
Dependencies are inferred from the claim text.