Topical products for use on intact skin or damaged skin for cosmetic use and/or as a medical device

A non-therapeutic cosmetic product comprising:

• at least one growth factor and at least one cytokine, secreted from a fibroblast cell culture, and
• hyaluronic acid, having a mean molecular weight in the range from 80 kDa to 1200 kDa;
• wherein said concentrate is obtainable by a process comprising the steps of:
• a. Providing a fibroblast cell culture in a cell culture medium;
• b. Stimulating the release of at least one growth factor and at least one cytokine into the cell culture medium of step a. to obtain a conditioned cell culture medium;
• c. Isolating the conditioned cell culture medium of step b. from the cell culture, to obtain an isolated conditioned cell culture medium;
• d. Concentrating the isolated conditioned cell culture medium of step c.,
• wherein said step b. of stimulating the release of at least one growth factor and at least one cytokine into the cell culture medium is carried out by subjecting said fibroblast cell culture to a step of nutrient deprivation.

A product comprising:

• at least one growth factor and at least one cytokine, secreted from a fibroblast cell culture, and
• hyaluronic acid, having a mean molecular weight in the range from 80 kDa to 1200 kDa;
• wherein said concentrate is obtainable by a process comprising the steps of:
• a. Providing a fibroblast cell culture in a cell culture medium;
• b. Stimulating the release of at least one growth factor and at least one cytokine into the cell culture medium of step a. to obtain a conditioned cell culture medium;
• c. Isolating the conditioned cell culture medium of step b. from the cell culture, to obtain an isolated conditioned cell culture medium;
• d. Concentrating the isolated conditioned cell culture medium of step c.,
• wherein said step b. of stimulating the release of at least one growth factor and at least one cytokine into the cell culture medium is carried out by subjecting said fibroblast cell culture to a step of nutrient deprivation.