Degradable elastomeric matrices, compositions comprising them, methods of preparing them and uses thereof
AssigneeAbleTx Ltd.
InventorsNir BETSER, Itai ADIN, Keren HADAR
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Abstract
Provided herein is an elastomeric matrix, comprising poly(vinyl alcohol) (PVOH); water, and one or more organic plasticizers. A combined mass ratio of the one or more organic plasticizers to said PVOH is at least 2:1; and the PVOH comprises PVOH of two or more types that differ from one another in one or both of hydrolysis degree (HD) and chain length.
Claims34
An elastomeric matrix, comprising:
- a. poly(vinyl alcohol) (PVOH);
- b. one or more organic plasticizers, each characterized by exhibiting at least two hydrogen bond forming functional groups;
- where a combined mass ratio of said one or more organic plasticizers to said PVOH is at least 2:1;
- and
- c. water constituting less than 50% wt of a total mass content of said elastomeric matrix;
- wherein said PVOH comprises PVOH of two or more types that differ from one another in one or both of hydrolysis degree (HD) and chain length.
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An ophthalmic device comprising the elastomeric matrix;
- the elastomeric matrix comprising:
- a. poly(vinyl alcohol) (PVOH);
- b. one or more organic plasticizers, each characterized by exhibiting at least two hydrogen bond forming functional groups;
- where a combined mass ratio of said one or more organic plasticizers to said PVOH is at least 2:1;
- and
- c. water constituting less than 50% wt of a total mass content of said elastomeric matrix;
- wherein said PVOH comprises PVOH of two or more types that differ from one another in one or both of hydrolysis degree (HD) and chain length.
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A medical device comprising two elastomeric matrices, each elastomeric matrix comprising:
- a. poly(vinyl alcohol) (PVOH);
- b. one or more organic plasticizers, each characterized by exhibiting at least two hydrogen bond forming functional groups;
- where a combined mass ratio of said one or more organic plasticizers to said PVOH is at least 2:1;
- and
- c. water constituting less than 50% wt of a total mass content of said elastomeric matrix;
- where said PVOH comprises PVOH of two or more types that differ from one another in one or both of hydrolysis degree (HD) and chain length;
- wherein the two matrices differ from one another in one or more of:
- a. ratio between the mass content of PVOH included in the matrix and the mass content of the matrix;
- b. ratio between the mass content of PVOH included in the matrix and the combined mass contents of the one or more plasticizers;
- c. the types of PVOH;
- and
- d. mass ratios between the types of PVOH.
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An elastomeric matrix, comprising:
- a. poly(vinyl alcohol) (PVOH);
- b. one or more organic plasticizers, each characterized by exhibiting at least two hydrogen bond forming functional groups;
- where a combined mass ratio of said one or more organic plasticizers to said PVOH is at least 2:1;
- and
- c. water constituting less than 50% wt of a total mass content of said elastomeric matrix;
- wherein said PVOH comprises only PVOH of chains shorter than 2000 units or shorter than 1000 units and degree of hydrolysis smaller than 90%, and
- said water makes less than 10% or less than 5% of the matrix.
Dependencies are inferred from the claim text.