Muscle cuff and skin regenerative peripheral nerve interface (rpni) with electrodes in muscle and skin

A method comprising:

• sensing, with sensing processing circuitry of an implant device, electrical signals from a muscle cuff tissue graft surgically attached to circumferentially surround an intact portion of a nerve of a subject;
• transmitting, with stimulating processing circuitry of the implant device, electrical signals to a dermal tissue graft surgically attached to an end of the nerve, the muscle cuff tissue graft and the dermal tissue graft each being surgically attached to the subject such that the each graft is entirely surrounded by and in direct contact with non-grafted tissue of the subject, the muscle cuff tissue graft being physically separated from the dermal tissue graft along the axis of the nerve such that the muscle cuff tissue graft is not in direct contact with the dermal tissue graft, the muscle cuff tissue graft being located on the intact portion of the nerve such that the nerve communicates electrical signals upstream and downstream from the location of the muscle cuff tissue graft on the intact portion of the nerve, the muscle cuff tissue graft and the dermal tissue graft each being an autograft of tissue harvested from the subject, devascularized, and deinnervated prior to being surgically attached to the subject, the nerve having reinnervated the muscle cuff tissue graft and the dermal tissue graft subsequent to each graft being surgically attached to the nerve;
• wherein:
• at least one sensing electrode is attached to, and in electrical communication with, the muscle cuff graft;
• at least one stimulating electrode is attached to, and in electrical communication with, the dermal tissue graft;
• the sensing processing circuitry is configured to receive electrical signals from the at least one sensing electrode, process the received electrical signals from the at least one sensing electrode, generate processed motor signal data corresponding to electrical signals received from the at least one sensing electrode, and to transmit the processed motor signal data to a prosthetic controller, the prosthetic controller being configured to control a prosthetic device based on the processed motor signal data transmitted from the sensing processing circuitry of the implant device;
• and
• the stimulating processing circuitry is configured to receive sensory feedback data from the prosthetic controller, generate processed sensory signal data based on the sensory feedback data, and transmit electrical signals to the at least one stimulating electrode corresponding to the processed sensory signal data.