Composite cuff regenerative peripheral nerve interface (cc-rpni)

A method comprising:

• receiving, with sensing processing circuitry of an implant device, electrical signals from a composite cuff tissue graft surgically attached to circumferentially surround an intact nerve of a subject;
• and
• transmitting, with stimulating processing circuitry of the implant device, electrical signals to the composite cuff tissue graft, the composite tissue graft including a muscle graft portion and a dermal graft portion, the composite tissue graft being surgically attached to the subject such that the composite tissue graft is entirely surrounded by and in direct contact with non-grafted tissue of the subject and such that the intact nerve additionally communicates electrical signals to other tissue of the subject both upstream and downstream from the location of the composite tissue graft, the muscle graft potion and the dermal graft portion each being an autograft of tissue harvested from the subject, devascularized, and deinnervated prior to being surgically attached to the subject, the nerve having reinnervated the muscle graft portion and the dermal graft portion of the composite tissue graft subsequent to the composite tissue graft being surgically attached to the nerve;
• wherein:
• at least one sensing electrode is attached to, and in electrical communication with, the muscle graft portion of the composite tissue graft;
• at least one stimulating electrode is attached to, and in electrical communication with, the dermal graft portion of the composite tissue graft;
• the sensing processing circuitry is configured to receive electrical signals from the at least one sensing electrode, process the received electrical signals from the at least one sensing electrode, generate processed motor signal data corresponding to electrical signals received from the at least one sensing electrode, and to transmit the processed motor signal data to a prosthetic controller, the prosthetic controller being configured to control a prosthetic device based on the processed motor signal data transmitted from the sensing processing circuitry of the implant device;
• and
• the stimulating processing circuitry is configured to receive sensory feedback data from the prosthetic controller, generate processed sensory signal data based on the sensory feedback data, and transmit electrical signals to the at least one stimulating electrode corresponding to the processed sensory signal data.