Ultrasound coupling agent
AssigneeSonoclear AS
InventorPeter BALMFORTH
Life of this patent
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Abstract
Provided herein are ultrasound coupling agents comprising a triglyceride and a phospholipid and methods of using them for ultrasound imaging of a subject. The ultrasound imaging may be invasive ultrasound imaging. Also provided herein are methods of preparing ultrasound coupling agents and methods of formulating ultrasound coupling agents.
Claims146
An aqueous ultrasound coupling agent consisting essentially of:
- (a) from about 60.0 g/L to about 80.0 g/L of at least one triglyceride;
- (b) from about 3.2 g/L to about 5.2 g/L of at least one phospholipid;
- (c) water;
- (d) pH buffer;
- and
- (e) glycerol.
An aqueous ultrasound coupling agent consisting essentially of:
- (a) at least one triglyceride;
- (b) at least one phospholipid;
- (c) water,
- (d) pH buffer;
- and
- (e) glycerol;
- and
- wherein the ratio of the at least one triglyceride to the at least one phospholipid is from about 13:1 to about 20:1 by weight.
An aqueous ultrasound coupling agent consisting essentially of:
- (a) between 5% w/v and 9% w/v of at least one triglyceride;
- (b) from about 0.2% w/v to about 1.2% w/v of at least one phospholipid;
- (c) water;
- (d) pH buffer;
- and
- (e) glycerol.
An aqueous ultrasound coupling agent consisting essentially of:
- (a) between 5% w/v and 9% w/v of at least one triglyceride;
- (b) at least one phospholipid, wherein the at least one phospholipid is present at about 0.42% w/V;
- (c) water;
- (d) pH buffer;
- and
- (e) glycerol.
An aqueous ultrasound coupling agent consisting essentially of:
- (a) between 5% w/v and 9% w/v of at least one triglyceride;
- (b) at least one phospholipid;
- (c) water;
- (d) pH buffer;
- and
- (e) glycerol.
An aqueous ultrasound coupling agent consisting essentially of:
- (a) between 5% w/v and 9% w/v of at least one triglyceride;
- (b) from about 0.2% w/v to about 1.2% w/v of at least one phospholipid;
- (c) water;
- (d) pH buffer;
- and
- (e) from about 21 g/L to about 26 g/L of glycerol.
An aqueous ultrasound coupling agent consisting essentially of:
- (a) about 7% w/v of a triglyceride;
- (b) about 4.2 g/L of a phospholipid;
- (c) about 23.7 g/L of glycerol;
- (d) water;
- and
- (e) a pH buffer.
An aqueous ultrasound coupling agent consisting essentially of:
- (a) about 7% w/v of a triglyceride;
- (b) about 8.4 g/L of a phospholipid;
- (c) glycerol;
- (d) water;
- and
- (e) a pH buffer;
- wherein the aqueous ultrasound coupling agent has an osmolality of from about 270 mOsm/kg to about 330 mOsm/kg.
An aqueous ultrasound coupling agent consisting essentially of:
- (a) about 7% w/v of a triglyceride;
- (b) about 8.4 g/L of a phospholipid;
- (c) from about 10 g/L to about 35 g/L glycerol;
- (d) water;
- and
- (e) a pH buffer.
An aqueous ultrasound coupling agent consisting essentially of:
- (a) between 5% w/v and 9% w/v of a triglyceride;
- (b) from about 7.4 g/L to about 9.4 g/L of a phospholipid;
- (c) from about 10 g/L to about 35 g/L glycerol;
- (d) water;
- and
- (e) a pH buffer.
An aqueous ultrasound coupling agent consisting essentially of:
- (a) between 5% and 9% w/v of a triglyceride;
- (b) from about 7.4 g/L to about 9.4 g/L of a phospholipid;
- (c) glycerol;
- (d) water;
- and
- (e) a pH buffer;
- wherein the aqueous ultrasound coupling agent has an osmolality of from about 270 mOsm/kg to about 330 mOsm/kg.
An aqueous ultrasound coupling agent consisting essentially of:
- (a) from about 60.0 to about 80.0 g/L of at least one triglyceride;
- (b) from about 3.2 to about 5.2 g/L of lecithin;
- (c) water;
- (d) pH buffer;
- and
- (e) glycerol.
An aqueous ultrasound coupling agent consisting essentially of:
- (a) at least one triglyceride;
- (b) lecithin;
- (c) water,
- (d) pH buffer;
- and
- (e) glycerol;
- and
- wherein the ratio of the at least one triglyceride to the at least one phospholipid is from about 13:1 to about 20:1 by weight.
An aqueous ultrasound coupling agent consisting essentially of:
- (a) between 5% w/v and 9% w/v of at least one triglyceride;
- (b) from about 0.2% w/v to about 1.2% w/v of lecithin;
- (c) water;
- (d) pH buffer;
- and
- (e) glycerol.
An aqueous ultrasound coupling agent consisting essentially of:
- (a) between 5% w/v and 9% w/v of at least one triglyceride;
- (b) about 0.42% w/v lecithin;
- (c) water;
- (d) pH buffer;
- and
- (e) glycerol.
An aqueous ultrasound coupling agent consisting essentially of:
- (a) between 5% w/v and 9% w/v of at least one triglyceride;
- (b) lecithin;
- (c) water;
- (d) pH buffer;
- and
- (e) glycerol.
An aqueous ultrasound coupling agent consisting essentially of:
- (a) between 5% w/v and 9% w/v of at least one triglyceride;
- (b) from about 0.2% w/v to about 1.2% w/v of lecithin;
- (c) water;
- (d) pH buffer;
- and
- (e) from about 21 g/L to about 26 g/L of glycerol.
An aqueous ultrasound coupling agent consisting essentially of:
- (a) 7% w/v of a triglyceride;
- (b) about 4.2 g/L lecithin;
- (c) about 23.7 g/L of glycerol;
- (d) water;
- and
- (e) a pH buffer.
An aqueous ultrasound coupling agent consisting essentially of:
- (a) about 7% w/v of a triglyceride;
- (b) about 8.4 g/L of lecithin;
- (c) glycerol;
- (d) water;
- and
- (e) a pH buffer;
- wherein the aqueous ultrasound coupling agent has an osmolality of from about 270 mOsm/kg to about 330 mOsm/kg.
An aqueous ultrasound coupling agent consisting essentially of:
- (a) about 7% w/v of a triglyceride;
- (b) about 8.4 g/L of lecithin;
- (c) from about 10 g/L to about 35 g/L glycerol;
- (d) water;
- and
- (e) a pH buffer.
An aqueous ultrasound coupling agent consisting essentially of:
- (a) between 5% w/v and 9% w/v of a triglyceride;
- (b) from about 7.4 g/L to about 9.4 g/L of lecithin;
- (c) from about 10 g/L to about 35 g/L glycerol;
- (d) water;
- and
- (e) a pH buffer.
An aqueous ultrasound coupling agent consisting essentially of:
- (a) between 5% and 9% w/v of a triglyceride;
- (b) from about 7.4 g/L to about 9.4 g/L of lecithin;
- (c) glycerol;
- (d) water;
- and
- (e) a pH buffer;
- wherein the aqueous ultrasound coupling agent has an osmolality of from about 270 mOsm/kg to about 330 mOsm/kg.
An aqueous ultrasound coupling agent comprising:
- (a) from about 60.0 to about 80.0 g/L of at least one triglyceride;
- (b) from about 3.2 to about 5.2 g/L of at least one phospholipid;
- (c) water;
- (d) pH buffer;
- and
- (e) glycerol;
- wherein the coupling agent does not include a stabilizer and does not include sodium chloride.
An aqueous ultrasound coupling agent comprising:
- (a) at least one triglyceride;
- (b) at least one phospholipid;
- (c) water;
- (d) pH buffer;
- and
- (e) glycerol;
- and
- wherein the ratio of the at least one triglyceride to the at least one phospholipid is from about 13:1 to about 20:1 by weight;
- wherein the coupling agent does not include a stabilizer and does not include sodium chloride.
An aqueous ultrasound coupling agent comprising:
- (a) between 5% w/v and 9% w/v of at least one triglyceride;
- (b) from about 0.2% w/v to about 1.2% w/v of at least one phospholipid;
- (c) water;
- (d) pH buffer;
- and
- (e) glycerol;
- wherein the coupling agent does not include a stabilizer and does not include sodium chloride.
An aqueous ultrasound coupling agent comprising:
- (a) between 5% w/v and 9% w/v of at least one triglyceride;
- (b) at least one phospholipid, wherein the at least one phospholipid is present at about 0.42% w/V;
- (c) water;
- (d) pH buffer;
- and
- (e) glycerol;
- wherein the coupling agent does not include a stabilizer and does not include sodium chloride.
An aqueous ultrasound coupling agent comprising:
- (a) between 5% w/v and 9% w/v of at least one triglyceride;
- (b) at least one phospholipid;
- (c) water;
- (d) pH buffer;
- and
- (e) glycerol;
- wherein the coupling agent does not include a stabilizer and does not include sodium chloride.
An aqueous ultrasound coupling agent comprising:
- (a) between 5% w/v and 9% w/v of at least one triglyceride;
- (b) from about 0.2% w/v to about 1.2% w/v of at least one phospholipid;
- (c) water;
- (d) pH buffer;
- and
- (e) from about 21 g/L to about 26 g/L of glycerol;
- wherein the coupling agent does not include a stabilizer and does not include sodium chloride.
An aqueous ultrasound coupling agent comprising:
- (a) about 7% w/v of a triglyceride;
- (b) about 4.2 g/L of a phospholipid;
- (c) about 23.7 g/L of glycerol;
- (d) water;
- and
- (e) a pH buffer;
- wherein the coupling agent does not include a stabilizer and does not include sodium chloride.
An aqueous ultrasound coupling agent comprising:
- (a) about 7% w/v of a triglyceride;
- (b) about 8.4 g/L of a phospholipid;
- (c) glycerol;
- (d) water;
- and
- (e) a pH buffer;
- wherein the aqueous ultrasound coupling agent has an osmolality of from about 270 mOsm/kg to about 330 mOsm/kg;
- wherein the coupling agent does not include a stabilizer and does not include sodium chloride.
An aqueous ultrasound coupling agent comprising:
- (a) about 7% w/v of a triglyceride;
- (b) about 8.4 g/L of a phospholipid;
- (c) from about 10 g/L to about 35 g/L glycerol;
- (d) water;
- and
- (e) a pH buffer;
- wherein the coupling agent does not include a stabilizer and does not include sodium chloride.
An aqueous ultrasound coupling agent comprising:
- (a) between 5% w/v and 9% w/v of a triglyceride;
- (b) from about 7.4 g/L to about 9.4 g/L of a phospholipid;
- (c) from about 10 g/L to about 35 g/L glycerol;
- (d) water;
- and
- (e) a pH buffer;
- wherein the coupling agent does not include a stabilizer and does not include sodium chloride.
An aqueous ultrasound coupling agent comprising:
- (a) between about 5% and about 9% w/v of a triglyceride;
- (b) from about 7.4 g/L to about 9.4 g/L of a phospholipid;
- (c) glycerol;
- (d) water;
- and
- (e) a pH buffer;
- wherein the aqueous ultrasound coupling agent has an osmolality of from about 270 mOsm/kg to about 330 mOsm/kg;
- wherein the coupling agent does not include a stabilizer and does not include sodium chloride.
An aqueous ultrasound coupling agent comprising:
- (a) from about 60.0 to about 80.0 g/L of at least one triglyceride;
- (b) from about 3.2 to about 5.2 g/L of lecithin;
- (c) water;
- (d) pH buffer;
- and
- (e) glycerol;
- wherein the coupling agent does not include a stabilizer and does not include sodium chloride.
An aqueous ultrasound coupling agent comprising:
- (a) at least one triglyceride;
- (b) lecithin;
- (c) water,
- (d) pH buffer;
- and
- (e) glycerol;
- and
- wherein the ratio of the at least one triglyceride to the at least one phospholipid is from about 13:1 to about 20:1 by weight;
- wherein the coupling agent does not include a stabilizer and does not include sodium chloride.
An aqueous ultrasound coupling agent comprising:
- (a) between 5% w/v and 9% w/v of at least one triglyceride;
- (b) from about 0.2% w/v to about 1.2% w/v of lecithin;
- (c) water;
- (d) pH buffer;
- and
- (e) glycerol;
- wherein the coupling agent does not include a stabilizer and does not include sodium chloride.
An aqueous ultrasound coupling agent comprising:
- (a) between 5% w/v and 9% w/v of at least one triglyceride;
- (b) about 0.42% w/v lecithin;
- (c) water;
- (d) pH buffer;
- and
- (e) glycerol;
- wherein the coupling agent does not include a stabilizer and does not include sodium chloride.
An aqueous ultrasound coupling agent comprising:
- (a) between 5% w/v and 9% w/v of at least one triglyceride;
- (b) lecithin;
- (c) water;
- (d) pH buffer;
- and
- (e) glycerol;
- wherein the coupling agent does not include a stabilizer and does not include sodium chloride.
An aqueous ultrasound coupling agent comprising:
- (a) between 5% w/v and 9% w/v of triglyceride;
- (b) from about 0.2% w/v to about 1.2% w/v of at least one lecithin;
- (c) water;
- (d) pH buffer;
- and
- (e) from about 21 g/L to about 26 g/L of glycerol;
- wherein the coupling agent does not include a stabilizer and does not include sodium chloride
An aqueous ultrasound coupling agent comprising:
- (a) about 7% w/v of a triglyceride;
- (b) about 4.2 g/L lecithin;
- (c) about 23.7 g/L of glycerol;
- (d) water;
- and
- (e) a pH buffer;
- wherein the coupling agent does not include a stabilizer and does not include sodium chloride.
An aqueous ultrasound coupling agent comprising:
- (a) about 7% w/v of a triglyceride;
- (b) about 8.4 g/L of lecithin;
- (c) glycerol;
- (d) water;
- and
- (e) a pH buffer;
- wherein the aqueous ultrasound coupling agent has an osmolality of from about 270 mOsm/kg to about 330 mOsm/kg;
- wherein the coupling agent does not include a stabilizer and does not include sodium chloride.
An aqueous ultrasound coupling agent comprising:
- (a) about 7% w/v of a triglyceride;
- (b) about 8.4 g/L of lecithin;
- (c) from about 10 g/L to about 35 g/L glycerol;
- (d) water;
- and
- (e) a pH buffer;
- wherein the coupling agent does not include a stabilizer and does not include sodium chloride.
An aqueous ultrasound coupling agent comprising:
- (a) between about 5% w/v and about 9% w/v of a triglyceride;
- (b) from about 7.4 g/L to about 9.4 g/L of lecithin;
- (c) from about 10 g/L to about 35 g/L glycerol;
- (d) water;
- and
- (e) a pH buffer;
- wherein the coupling agent does not include a stabilizer and does not include sodium chloride.
An aqueous ultrasound coupling agent comprising:
- (a) between about 5% and about 9% w/v of a triglyceride;
- (b) from about 7.4 g/L to about 9.4 g/L of lecithin;
- (c) glycerol;
- (d) water;
- and
- (e) a pH buffer;
- wherein the aqueous ultrasound coupling agent has an osmolality of from about 270 mOsm/kg to about 330 mOsm/kg;
- wherein the coupling agent does not include a stabilizer and does not include sodium chloride.
An aqueous ultrasound coupling agent comprising:
- (a) about 7% w/v of a triglyceride;
- (b) about 4.2 g/L of at least one phospholipid;
- (c) about 23.7 g/L of glycerol;
- (d) water;
- and
- (e) a pH buffer.
An aqueous ultrasound coupling agent comprising:
- (a) about 7% w/v of a triglyceride;
- (b) about 4.2 g/L lecithin;
- (c) about 23.7 g/L of glycerol;
- (d) water;
- and
- (e) a pH buffer.
An aqueous ultrasound coupling agent comprising:
- (a) about 7% w/v of a triglyceride;
- (b) about 8.4 g/L of at least one phospholipid;
- (c) glycerol;
- (d) water;
- and
- (e) a pH buffer;
- wherein the aqueous ultrasound coupling agent has an osmolality of from about 270 mOsm/kg to about 330 mOsm/kg.
An aqueous ultrasound coupling agent comprising:
- (a) about 7% w/v of a triglyceride;
- (b) about 8.4 g/L lecithin;
- (c) glycerol;
- (d) water;
- and
- (e) a pH buffer;
- wherein the aqueous ultrasound coupling agent has an osmolality of from about 270 mOsm/kg to about 330 mOsm/kg.
Dependencies are inferred from the claim text.