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US 2026/0306018 A1Published application
Methods of determining glucose hypometabolism-induced energy crisis and treatments thereof
AssigneeSenovia Biosciences LLC
InventorJoel R. Anderson, II
Life of this patent
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Abstract
The present disclosure provides systems, methods, compositions, and algorithms for treating a subject diagnosed with a glucose hypometabolic disorder (e.g., Alzheimer's disease, Parkinson's disease, or heart failure).
Claims24
A method of treating a subject diagnosed with a glucose hypometabolic disorder, comprising:
- (a) measuring a glucose metabolism deficit (G_Diff) in one or more tissues of the subject using at least one diagnostic technique to obtain a quantitative indication of the subject's impaired glucose utilization;
- (b) calculating a personalized exogenous ketone dosage (K) based on the measured G_Diff, wherein said calculation comprises applying at least one algorithm that correlates the measured G_Diff to the exogenous ketone intake required to at least partially compensate for the subject's impaired glucose utilization;
- and
- (c) administering an exogenous ketone composition to the subject in accordance with the calculated personalized exogenous ketone dosage,
- wherein the administered exogenous ketone composition provides an alternative metabolic fuel to the affected tissues, thereby addressing the subject's glucose hypometabolism.
2 more elements
-31. (canceled)
A method of treating a subject diagnosed with a glucose hypometabolic disorder, comprising:
- (a) measuring a glucose metabolism deficit (G_Diff) in one or more tissues of the subject using at least one diagnostic technique;
- (b) calculating a personalized exogenous ketone dosage (K) based on the measured G_Diff using Formula (I)
- K
- =
- G_Diff
- ×
- (
- 4
- /
- 4.7
- )
- ×
- F
- ×
- p
- ,
- (
- I
- )
- wherein F is an efficiency factor and p is a partition factor representing tissue-specific ketone uptake capacity;
- and
- (c) administering an exogenous ketone composition to the subject in accordance with the calculated dosage, wherein the administered exogenous ketone composition provides an alternative metabolic fuel that compensates for the subject's glucose hypometabolism.
19 more elements
-44. (canceled)
A method of treating a patient in need of therapy by establishing a therapeutic ketonemic state, the method comprising:
- administering one or more ketone-elevating agents to the patient and controlling the patient's blood β-hydroxybutyrate (BHB) level to maintain BHB within a target range effective for therapy, for a duration sufficient to achieve a therapeutic benefit, wherein said therapeutic ketonemic state is achieved without requiring the patient to adhere to a ketogenic diet.
-51. (canceled)
-60. (canceled)
Dependencies are inferred from the claim text.