High-volume bodily fluid collection devices and related systems and methods

A device comprising:

• a housing having a surface configured to be positioned against skin of a subject, the housing having an opening extending through the surface;
• a flexible membrane stretched across the opening;
• a floating island carried by the flexible membrane and adhesively coupled to the flexible membrane;
• and
• a skin-piercing assembly positioned at least partially within the housing and having a blade configured to pierce the skin of the subject when deployed;
• and
• wherein—
• movement of the skin-piercing assembly away from the opening draws a vacuum within at least a portion of the housing, and
• the skin of the subject is drawn at least partially through the opening in the housing and assumes a two-tiered shape therein when subject to the vacuum.

A method of collecting blood from a patient, comprising:

• placing a bodily fluid collection device on skin of the patient;
• pressing an actuator of the bodily fluid collection device to deploy a blade to cut the patient's skin;
• releasing the actuator to create a vacuum within the bodily fluid collection device to increase bodily fluid flow from a wound in the patient's skin;
• collecting a desired sample in a collection reservoir;
• and
• removing the bodily fluid collection device from the skin.