Method for measuring polypeptide aggregate, calibrator, complex, and method for producing the same
AssigneeSysmex Corporation
InventorsIshita Gupta, Hui Zhou, Kazuya Matsumoto, Masahiro Miura
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Abstract
Provided is a method for measuring a polypeptide aggregate in a sample, wherein the method comprises obtaining information regarding a concentration of the polypeptide aggregate in the sample using a calibrator, and the calibrator comprises a complex comprising: an oligopeptide comprising an epitope of the polypeptide aggregate; a hydrophilic polymer chain not comprising the epitope; and a carrier particle.
Claims20
A method for measuring a polypeptide aggregate in a sample, comprising obtaining information regarding a concentration of the polypeptide aggregate in the sample using a calibrator,
- wherein the calibrator comprises a complex comprising:
- an oligopeptide comprising an epitope of the polypeptide aggregate;
- a hydrophilic polymer chain not comprising the epitope;
- and a carrier particle.
A calibrator for obtaining information regarding a concentration of a polypeptide aggregate in a sample, comprising a complex comprising:
- an oligopeptide comprising an epitope of the polypeptide aggregate;
- a hydrophilic polymer chain not comprising the epitope;
- and a carrier particle.
A method for producing a complex for use to obtain information regarding a concentration of a polypeptide aggregate in a sample, comprising immobilizing an oligopeptide comprising an epitope of the polypeptide aggregate and a hydrophilic polymer chain not comprising the epitope on a surface of a carrier particle.
Dependencies are inferred from the claim text.