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US 2026/0297679 A1Published application
Assays for monitoring inhibition of rna helicase dhx9
AssigneeAccent Therapeutics, Inc.
InventorsJennifer Castro, Scott Ribich, David Patrick Brennan
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Abstract
The present disclosure provides methods of measuring the activity of a DHX9 inhibitor in cells or in a subject, the methods comprising measuring the level of an Alu-mediated circular RNA induced by the DHX9 inhibitor.
Claims53
A method of measuring activity of a DHX9 inhibitor in a cell, comprising:
- contacting a cell with the DHX9 inhibitor;
- and
- measuring the level of an Alu-mediated circular RNA (Alu-circRNA) in the cell.
A method of measuring activity of a DHX9 inhibitor in a subject, comprising:
- administering a DHX9 inhibitor to a subject;
- and
- measuring the level of an Alu-mediated circular RNA (Alu-circRNA) in a biological sample from the subject.
A method of measuring activity of a DHX9 inhibitor in a subject, comprising:
- measuring the level of Alit-mediated circular RNA (Alu-circRNA) in a biological sample from a subject, wherein the subject is being treated with a DHX9 inhibitor.
A method of monitoring treatment of a subject with a DHX9 inhibitor, comprising:
- administering a DHX9 inhibitor to the subject;
- and
- obtaining information as to the level of Alu-mediated circular RNA (Alu-circRNA) in a biological sample obtained from the subject after administration of the DHX9 inhibitor.
Dependencies are inferred from the claim text.