Wrinkle determination of a human individual

Computer-readable medium having stored computer-executable instructions for causing a computer to perform a method for determining the predicted wrinkle grade of human skin comprising:

• a) inputting at least one value of a determined methylation level of at least one CpG-dinucleotide of a specific region of at least one chromosome of said skin cells or inputting at least one value of a determined expression level of at least one gene of said skin cells;
• b) comparing said value of the determined methylation level with stored data representing a correlation between the methylation level of said CpG-dinucleotide and the visual wrinkle grade of at least one human individual or comparing said value of gene expression level with stored data representing a correlation between the gene expression level and the visual wrinkle grade of at least one human individual;
• and
• c) displaying the predicted wrinkle grade.