Small molecules for increasing precise genome editing efficiency
AssigneeMax-Planck-Gesellschaft zur Forderung der Wissenschaften e.V.
InventorsStephan RIESENBERG, Tomislav MARICIC
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Abstract
Aspects of the present invention relates to compounds suitable to increase precise genome editing efficiency in a eukaryotic target cell or target organism. Thus, the present invention can be applied in gene therapy. The compound may be of formula (I) or (II). The compound may be selected from Nedisertib (M3814) or a physiologically acceptable salt or solvate thereof. The compound may further include introducing at least one further compound different from a compound of formula (I) or (II). Aspects of the present invention also relate to a method for editing the genome of a eukaryotic target cell or eukaryotic target organism comprising introducing a compound of formula (I) or (II) into the target cell or target organism.
Claims21
1-19. (canceled)
A method for editing a genome of a eukaryotic target cell or a eukaryotic target organism, wherein the eukaryotic target cell or eukaryotic target organism comprises a DNA cleavage enzyme, the method comprising introducing Nedisertib (M3814) or a physiologically acceptable salt or solvate thereof into the target cell or target organism.
Dependencies are inferred from the claim text.