Microbe-gut-joint axis multi-organ chip and preparation method thereof

Abstract

The present invention discloses a microbe-gut-joint axis multi-organ chip, comprising: an upper-layer chip, comprising a microbe-gut symbiosis module; a lower-layer chip, comprising a cartilage organoid module; a middle-layer chip, located between the upper-layer chip and the lower-layer chip, comprising a vascular microchannel module and a synovial organoid module; a porous membrane, disposed between the upper-layer chip and the middle-layer chip; and at least one microvalve, configured to dynamically control liquid flow between specific modules within the chip; wherein the microbe-gut symbiosis module and the vascular microchannel module overlap partially in space, and are physically separated by the porous membrane. The invention also relates to a method of preparing the disclosed microbe-gut-joint axis multi-organ chip.

Dependencies are inferred from the claim text.