In Situ Functionalized Symmetric Skinless Mixed Matrix Membrane Adsorbers with Embedded Polymeric Particles and Networks, and Related Compositions, Methods, and Systems

A method of making an in-situ functionalized skinless and symmetric membrane adsorber, said method comprising:

• (a) preparing a dope solution, said preparing comprising:
• (i) contacting a base polymer, a base polymer solvent, and a particle precursor with a crosslinker and/or an initiator for a time and under a condition sufficient to permit the in-situ synthesis of intermediate polymeric microparticles and/or nanoparticles to form an intermediate dope solution, wherein said base polymer solvent has a base polymer solvent Hildebrand solubility parameter (delta-s);
• and
• (ii) contacting said intermediate dope solution with an organic-compatible functional reagent for a time and under a condition sufficient to permit the in-situ functionalization of said intermediate polymeric microparticles and/or nanoparticles to form a final dope solution, wherein said in-situ functionalization forms functional groups selected from the group consisting of:
• Strong Base (SB) Anion Exchange (AEX) groups, Cation Exchange (CEX) groups, Hydrophobic Interaction Chromatography (HIC) groups, Chelating groups and Fluorophilic groups;
• (b) casting said final dope solution to form a nascent membrane;
• and
• (c) inducing phase separation of said nascent membrane by a controlled, gradual demixing process to form the in-situ functionalized membrane adsorber, said membrane adsorber having a symmetric and skinless morphology.