High-affinity t cell receptor for identifying kras mutation and use thereof
AssigneeXlifesc, Ltd.
InventorsYushuang LIANG, Kai ZHAN, Zhen PENG, Hanli SUN, Cuiqiong ZHANG, Jiao HUANG, Zhiming WENG, Yingyi MEI
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Abstract
Provided is a TCR having the characteristics of binding to a VVVGADGVGK-HLA A1101 complex. Also provided are a multivalent TCR complex, a nucleic acid molecule encoding the TCR, a vector comprising the nucleic acid molecule, a cell expressing the TCR, and a pharmaceutical composition comprising the described substance, which can be used for preparing a medicament for diagnosing, treating, and preventing a KRAS G12D positive disease. Also provided is a preparation method for the TCR.
Claims26
A T cell receptor (TCR) comprising a TCRα chain variable domain and a TCRβ chain variable domain, wherein the T cell receptor has the activity of binding to the VVVGADGVGK-HLA A1101 complex;
- and the amino acid sequence of the TCRα chain variable domain has at least 90% sequence homology with the amino acid sequence shown in SEQ ID NO:
- 1, and the amino acid sequence of the TCRβ chain variable domain has at least 90% sequence homology with the amino acid sequence shown in SEQ ID NO:
- 2.
Dependencies are inferred from the claim text.