US 2026/0297141 A1 · TP0751 CHIMERA-CONTAINING VACCINE

Tp0751 chimera-containing vaccine

AssigneesUVic Industry Partnerships Inc., University of Washington

InventorsCaroline E. Cameron, Martin J. Boulanger, Alloysius Martin Gomez Thomas, Simon Houston, Raghavendran Ramaswamy, Lexie Thompson, Sheila A. Lukehart, Lorenzo Giacani, Barbara Molini, Anna Wald

Life of this patent

Estimating the term…

Abstract

Provided are chimeric Tp0751 (99-237) peptides containing one or more non-native epitopes that replace all or of part of one or more loops 1-8 of the native Tp0751 (99-237) peptide. The non-native epitopes can be from one or more sexually transmitted infections (STIs), such as Treponema pallidum, Chlamydia, or Neisseria gonorrhoeae. Also provided are nucleic acid molecules that encode the chimeric Tp0751 (99-237) peptides. Methods of using the chimeric Tp0751 (99-237) peptides to stimulate an immune response, for example to treat syphilis or other sexually STIs are provided.

Claims25

Dependent claims

A chimeric Tp0751 (99-237) peptide, comprising:

at least one non-native epitope peptide that replaces all of or part of one or more loops of a native Tp0751 (99-237) peptide,
wherein the native Tp0751 (99-237) peptide sequence is SEQ ID NO:
3, and
wherein the one or more loops of the native Tp0751 (99-237) peptide are
loop 1 GEQGALQHLLA (SEQ ID NO:
4),
loop 2 QTEISPNSGDIHP (SEQ ID NO:
5),
loop 3 REHA (aa 147-150 of SEQ ID NO:
2),
loop 4 AS (aa 157-158 of SEQ ID NO:
2),
loop 5 RK (aa 172-173 of SEQ ID NO:
2),
loop 6 NTAISSI (SEQ ID NO:
6),
loop 7 HE (aa 198-199 of SEQ ID NO:
2), and
loop 8 aa DVARLKIGSTSMWD (SEQ ID NO:
7).

17 more elements

Dependencies are inferred from the claim text.

Facts

Application

19/479,497Filed 15 Nov 2023

Priority

28 Apr 2023

Published

1 Oct 2026

Term ends

Not estimatedThe source records don’t support an estimate.

Classification12 codes

C07K 14/20
From bacteria: from Spirochaetales , e.g. Treponema, Leptospira
A61K 31/43
Condensed with heterocyclic ring systems: compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring…
A61K 31/546
Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula: [IMAGE…: containing…
A61K 31/65
Medicinal preparations containing organic active ingredients: tetracyclines