Hdac1/2 selective inhibitor and use thereof

A compound represented by general formula (1) or an isomer thereof, a crystalline form thereof, a pharmaceutically acceptable salt thereof, a hydrate thereof, or a solvate thereof:

• wherein in general formula (1):
• X is —NH2 or —OH;
• Cy is (C6-C14) aryl or (5-14 membered) heteroaryl, wherein the (C6-C14) aryl or (5-14 membered) heteroaryl may be each independently and optionally substituted with 1, 2, 3, or 4 R5;
• ring A is (C6-C14) aryl, (5-14 membered) heteroaryl, (C3-C14) cycloalkyl, or (3-14 membered) heterocycloalkyl;
• R1 is H, D, or halogen;
• R2 is H, D, halogen, (C1-C4) alkyl, (C1-C4) alkoxy, (C1-C4) haloalkyl, (C2-C4) alkenyl, (C2-C4) alkynyl, (C3-C6) cycloalkyl, or (3-6 membered) heterocycloalkyl;
• R3 is (C1-C6) alkyl, (C1-C6) alkoxy, (C1-C6) haloalkyl, (C2-C4) alkenyl, (C2-C4) alkynyl, (C3-C6) cycloalkyl, or (3-6 membered) heterocycloalkyl, wherein the (C1-C6) alkyl, (C1-C6) alkoxy, (C1-C6) haloalkyl, (C2-C4) alkenyl, (C2-C4) alkynyl, (C3-C6) cycloalkyl, or (3-6 membered) heterocycloalkyl may be each independently and optionally substituted with 1, 2, 3, or 4 Ra;
• R4 is (C1-C6) alkyl, (C1-C6) alkoxy, (C1-C6) haloalkyl, (C2-C4) alkenyl, (C2-C4) alkynyl, (C3-C6) cycloalkyl, or (3-6 membered) heterocycloalkyl, wherein the (C1-C6) alkyl, (C1-C6) alkoxy, (C1-C6) haloalkyl, (C2-C4) alkenyl, (C2-C4) alkynyl, (C3-C6) cycloalkyl, or (3-6 membered) heterocycloalkyl may be each independently and optionally substituted with 1, 2, 3, or 4 Rb;
• or R3 and R4, together with the S atom to which they are attached, form (3-16 membered) heterocycloalkyl, wherein the (3-16 membered) heterocycloalkyl may be each independently and optionally substituted with 1, 2, 3, or 4 R6;
• R5 is H, D, halogen, hydroxy, amino, cyano, nitro, —ORa, —NRaRb, —C(O)Ra, —CO2Ra, —(CH2)mRa, —(CH2)mCO2Ra, —(CH2)m—CONRaRb, —S(O)pRa, —S(O)pNRaRb, —CONRaRb, —C(═NRa)—NRaRb, —NRaCORb, —CRaCONRaRb, —NRaCO2Ra, —NRaS(O)pNRaRb, —NRaS(O)pRa, —P(O)pRaRb, (C1-C8) alkyl, (C1-C8) alkoxy, (C1-C8) haloalkyl, (C2-C8) alkenyl, (C2-C8) alkynyl, (C3-C14) cycloalkyl, (3-14 membered) heterocycloalkyl, (C6-C14) aryl, (5-14 membered) heteroaryl, —(C1-C8) alkylene-(C3-C14) cycloalkyl, —(C1-C8) alkylene-(3-14 membered) heterocycloalkyl, —(C1-C8) alkylene-(C6-C14) aryl, or —(C1-C8) alkylene-(5-14 membered) heteroaryl, wherein the (C1-C8) alkyl, (C1-C8) alkoxy, (C1-C8) haloalkyl, (C2-C8) alkenyl, (C2-C8) alkynyl, (C3-C14) cycloalkyl, (3-14 membered) heterocycloalkyl, (C6-C14) aryl, (5-14 membered) heteroaryl, —(C1-C8) alkylene-(C3-C14) cycloalkyl, —(C1-C8) alkylene-(3-14 membered) heterocycloalkyl, —(C1-C8) alkylene-(C6-C14) aryl, or —(C1-C8) alkylene-(5-14 membered) heteroaryl may be each independently and optionally substituted with 1, 2, 3, or 4 Rc;
• R6 is H, D, halogen, hydroxy, amino, cyano, nitro, —ORa, —NRaRb, —C(O)Ra, —CO2Ra, —(CH2)mRa, —(CH2)mCO2Ra, —(CH2)m—CONRaRb, —S(O)pRa, —S(O)pNRaRb, —CONRaRb, —C(═NRa)—NRaRb, —NRaCORb, —CRaCONRaRb, —NRaCO2Ra, —NRaS(O)pNRaRb, —NRaS(O)pRa, —P(O)pRaRb, (C1-C8) alkyl, (C1-C8) alkoxy, (C1-C8) haloalkyl, (C2-C8) alkenyl, (C2-C8) alkynyl, (C3-C14) cycloalkyl, (3-14 membered) heterocycloalkyl, (C6-C14) aryl, (5-14 membered) heteroaryl, —(C1-C8) alkylene-(C3-C14) cycloalkyl, —(C1-C8) alkylene-(3-14 membered) heterocycloalkyl, —(C1-C8) alkylene-(C6-C14) aryl, or —(C1-C8) alkylene-(5-14 membered) heteroaryl, wherein the (C1-C8) alkyl, (C1-C8) alkoxy, (C1-C8) haloalkyl, (C2-C8) alkenyl, (C2-C8) alkynyl, (C3-C14) cycloalkyl, (3-14 membered) heterocycloalkyl, (C6-C14) aryl, (5-14 membered) heteroaryl, —(C1-C8) alkylene-(C3-C14) cycloalkyl, —(C1-C8) alkylene-(3-14 membered) heterocycloalkyl, —(C1-C8) alkylene-(C6-C14) aryl, or —(C1-C8) alkylene-(5-14 membered) heteroaryl may be each independently and optionally substituted with 1, 2, 3, or 4 Rc;
• or when 2 R6 are attached to the same atom, the 2 R6, together with the atom to which they are attached, may form one oxo group, (C3-C6) cycloalkyl group, or (3-6 membered) heterocycloalkyl group;
• Ra and Rb are each independently —H, -D, halogen, hydroxy, amino, cyano, nitro, (C1-C8) alkyl, (C1-C8) alkoxy, (C1-C8) haloalkyl, (C2-C8) alkenyl, (C2-C8) alkynyl, (C3-C14) cycloalkyl, (3-14 membered) heterocycloalkyl, (C6-C14) aryl, (5-14 membered) heteroaryl, —(C1-C8) alkylene-(C3-C14) cycloalkyl, —(C1-C8) alkylene-(3-14 membered) heterocycloalkyl, —(C1-C8) alkylene-(C6-C14) aryl, or —(C1-C8) alkylene-(5-14 membered) heteroaryl, wherein the (C1-C8) alkyl, (C1-C8) alkoxy, (C1-C8) haloalkyl, (C2-C8) alkenyl, (C2-C8) alkynyl, (C3-C14) cycloalkyl, (3-14 membered) heterocycloalkyl, (C6-C14) aryl, (5-14 membered) heteroaryl, —(C1-C8) alkylene-(C3-C14) cycloalkyl, —(C1-C8) alkylene-(3-14 membered) heterocycloalkyl, —(C1-C8) alkylene-(C6-C14) aryl, or —(C1-C8) alkylene-(5-14 membered) heteroaryl may be each independently and optionally substituted with 1, 2, 3, or 4 Rc;
• or when 2 Ra are attached to the same atom, the 2 Ra may form one oxo group;
• or when 2 R are attached to the same atom, the 2 R may form one oxo group;
• or Ra and Rb attached to the same atom, together with the atom to which they are attached, form one (5-7 membered) heterocycloalkyl group or (C3-C9) cycloalkyl group, wherein the (5-7 membered) heterocycloalkyl group or (C3-C9) cycloalkyl group is each independently and optionally substituted with 1, 2, 3, or 4 Rc;
• Rc is —H, -D, halogen, hydroxy, amino, cyano, nitro, (C1-C8) alkyl, (C1-C8) alkoxy, (C1-C8) haloalkyl, (C2-C8) alkenyl, (C2-C8) alkynyl, (C3-C14) cycloalkyl, (3-14 membered) heterocycloalkyl, (C6-C14) aryl, (5-14 membered) heteroaryl, —(C1-C8) alkylene-(C1-C8) alkoxy, —(C1-C8) alkylene-(C3-C14) cycloalkyl, —(C1-C8) alkylene-(3-14 membered) heterocycloalkyl, —(C1-C8) alkylene-(C6-C14) aryl, or —(C1-C8) alkylene-(5-14 membered) heteroaryl;
• or when 2 Rc are attached to the same atom, the 2 Rc may form one oxo group, (C3-C6) cycloalkyl group, or (3-6 membered) heterocycloalkyl group;
• m, n, and p are integers of 0, 1, or 2.