Oxazole trpml1 agonists and uses thereof

A compound of Formula (I), or a pharmaceutically acceptable salt, solvate, or stereoisomer thereof:

• wherein:
• R1 is C1-C6alkyl optionally substituted with one or more R;
• R2 is C1-C6alkyl optionally substituted with one or more R;
• or R1 and R2 are taken together to form a heterocycloalkyl or heteroaryl;
• each optionally substituted with one or more R1a;
• each R1a is independently deuterium, halogen, —CN, —NO2, —OH, —ORa, —OC(═O)Ra, —OC(═O)ORb, —OC(═O)NRcRd, —SH, —SRa, —S(═O)Ra, —S(═O)2Ra, —S(═O)2NRcRd, —NRcRd, —NRbC(═O)NRcRd, —NRbC, (═O)Ra, —NRbC, (═O)ORb, —NRbS(═O)Ra, —NRbS(═O)2Ra, —C(═O)Ra, —C(═O)ORb, —C(═O)NRcRd, C1-C6alkyl, C1-C6haloalkyl, C1-C6deuteroalkyl, C2-C6alkenyl, C2-C6alkynyl, C1-C6hydroxyalkyl, C1-C6aminoalkyl, C1-C6heteroalkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, C1-C6alkylene (cycloalkyl), C1-C6alkylene (heterocycloalkyl), C1-C6alkylene (aryl), or C1-C6alkylene (heteroaryl);
• wherein each alkyl, alkylene, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl is independently and optionally substituted with one or more R;
• or two R1a on the same atom are taken together to form an oxo;
• R3 is C1-C6alkyl, C1-C6haloalkyl, C1-C6deuteroalkyl, C2-C6alkenyl, C2-C6alkynyl, C1-C6hydroxyalkyl, C1-C6aminoalkyl, C1-C6heteroalkyl, cycloalkyl, or heterocycloalkyl, wherein each alkyl, alkenyl, alkynyl, cycloalkyl, and heterocycloalkyl is independently and optionally substituted with one or more R;
• Ring A is aryl or heteroaryl;
• each R4 is independently deuterium, halogen, —CN, —NO2, —OH, —ORa, —OC(═O)Ra, —OC(═O)ORb, —OC(═O)NRcRd, —O-cycloalkyl, —O-heterocycloalkyl, —SH, —SRa, —S(—O)Ra, —S(═O)2Ra, —S(═O)2NRcRd, —NRcRd, —NRDC(═O)NRcRd, —NRbC, (═O)Ra, —NRbC, (═O)ORb, —NRbS(═O)Ra, —NRbS(═O)2Ra, —NRb— cycloalkyl, —NRb-heterocycloalkyl, —C(═O)Ra, —C(═O)ORb, —C(═O)NRcRd, C1-C6alkyl, C1-C6haloalkyl, C1-C6deuteroalkyl, C2-C6alkenyl, C2-C6alkynyl, C1-C6hydroxyalkyl, C1-C6aminoalkyl, C1-C6heteroalkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, C1-C6alkylene (cycloalkyl), C1-C6alkylene (heterocycloalkyl), C1-C6alkylene (aryl), or C1-C6alkylene (heteroaryl);
• wherein each alkyl, alkylene, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl is independently and optionally substituted with one or more R;
• n is 0-4;
• each Ra is independently C1-C6alkyl, C1-C6haloalkyl, C1-C6deuteroalkyl, C1-C6hydroxyalkyl, C1-C6aminoalkyl, C1-C6heteroalkyl, C2-C6alkenyl, C2-C6alkynyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, C1-C6alkylene (cycloalkyl), C1-C6alkylene (heterocycloalkyl), C1-C6alkylene (aryl), or C1-C6alkylene (heteroaryl);
• wherein each alkyl, alkylene, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl is independently and optionally substituted with one or more R;
• each Rb is independently hydrogen, C1-C6alkyl, C1-C6haloalkyl, C1-C6deuteroalkyl, C1-C6hydroxyalkyl, C1-C6aminoalkyl, C1-C6heteroalkyl, C2-C6alkenyl, C2-C6alkynyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, C1-C6alkylene (cycloalkyl), C1-C6alkylene (heterocycloalkyl), C1-C6alkylene (aryl), or C1-C6alkylene (heteroaryl);
• wherein each alkyl, alkylene, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl is independently and optionally substituted with one or more R;
• each Rc and Rd are independently hydrogen, C1-C6alkyl, C1-C6haloalkyl, C1-C6deuteroalkyl, C1-C6hydroxyalkyl, C1-C6aminoalkyl, C1-C6heteroalkyl, C2-C6alkenyl, C2-C6alkynyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, C1-C6alkylene (cycloalkyl), C1-C6alkylene (heterocycloalkyl), C1-C6alkylene (aryl), or C1-C6alkylene (heteroaryl);
• wherein each alkyl, alkylene, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl is independently and optionally substituted with one or more R;
• or Rc and Rd are taken together with the atom to which they are attached to form a heterocycloalkyl optionally substituted with one or more R;
• and
• each R is independently deuterium, halogen, —CN, —OH, —S(═O)C1-C3alkyl, —S(═O)2C1-C6alkyl, —S(═O)2NH2, —S(═O)2NHC1-C3alkyl, —S(═O)2N(C1-C3alkyl)2, —NH2, —NHC1-C3alkyl, —N(C1-C3alkyl)2, —C(═O)C1-C3alkyl, —C(═O) OH, —C(═O)OC1-C3alkyl, —C(═O)NH2, —C(═O)NHC1-C3alkyl, —C(═O)N(C1-C3alkyl)2, C1-C3alkyl, C1-C3alkoxy, C1-C3haloalkyl, C1-C3deuteroalkyl, C1-C3haloalkoxy, C1-Cshydroxyalkyl, C1-C3aminoalkyl, C1-C3heteroalkyl, C3-C3cycloalkyl, or 3- to 6-membered heterocycloalkyl;
• wherein each cycloalkyl and heterocycloalkyl is independently optionally substituted with one or more halogen;
• or two R on the same atom form an oxo.