Heterocyclic compound acting on g12d mutant kras protein

A compound of formula (I) or a salt thereof,

• wherein
• A is CRA or N,
• RA is H, optionally substituted C1-3 alkyl, or cyano,
• Q is CRQ or N,
• RQ is H, halogen, optionally substituted C1-3 alkyl, C3-6 cycloalkyl, or vinyl,
• E is CH or N,
• R1 is naphthyl optionally substituted with one or two groups selected from the group consisting of optionally substituted C1-3 alkyl, cyano, OH, and halogen;
• or R1 is a group selected from the group consisting of formula (II), formula (III), and formula (IV),
• R1a, R1b, and R1c, which are the same as or different from each other, are H, optionally substituted C1-3 alkyl, vinyl, or halogen,
• R2 is —V1—V2 or W,
• V1 is a bond, —CH2—, —O—, —S—, or —N(RV1)—,
• RV1 is H or optionally substituted C1-3 alkyl,
• V2 is formula (V) or formula (VI),
• W is formula (VII), formula (VII-2), or a 7-membered to 9-membered bridged heterocycloalkyl containing one to two nitrogen atoms,
• each R2a, which is the same as or different from each other, are OH, OCH3, F, or optionally substituted C1-3 alkyl, where R2a is attached only to a carbon atom that is an atom forming a ring selected from the group consisting of an azetidine ring represented by formula (V), a pyrrolidine ring represented by formula (VI), a piperidine ring represented by formula (VII) and a piperazine ring represented by formula (VII-2),
• m is an integer of 0 to 2,
• R3 is optionally substituted C1-6 alkyl, optionally substituted heterocycloalkyl, or optionally substituted heteroaryl,
• X is a bond, —CH2—, —O—, —S—, or —NR4X—,
• R4X is H or optionally substituted C1-3 alkyl,
• Y1 is —O-(optionally substituted C1-3 alkylene)-*Y2, —S-(optionally substituted C1-3 alkylene)-*Y2, —SO2-(optionally substituted C1-3 alkylene)-*Y2, —NR— (optionally substituted C1-3 alkylene)-*Y2, -(optionally substituted C1-3 alkylene)-O—*Y2, -(optionally substituted C1-3 alkylene)-S—*Y2, -(optionally substituted C1-3 alkylene)-SO2—*Y2 or -(optionally substituted C1-3 alkylene)-NRY—*Y2(*Y2 represents a linking moiety to Y2),
• RY is H or optionally substituted C1-3 alkyl,
• Y2 is a bond, optionally substituted phenylene, or optionally substituted heteroarylene,
• Linker is one group chemically linking Y2 to EUB, and
• EUB is a group capable of binding to one E3 ubiquitin ligase selected from the group consisting of cereblon, IAP, MDM2, DCAF11, DCAF15, DCAF16, BIRC2, KEAP1, RNF4, RNF114, FEM1B. and AhR).