Substituted acetylene compound derivatives and their pharmaceutical use

A compound of the following Formula (I):

• wherein:
• each of R1, R2, R3, R4 and R5 is independently selected from the group consisting of hydrogen, C1-C6 alkyl, C2-C6 alkenyl, C1-C6 alkoxy, halogen, 3-10 membered cycloalkyl, cyano, hydroxy, and —NRxRy, wherein each of said alkyl, alkenyl, alkoxy, and cycloalkyl is independently optionally substituted with one or more selected from C1-C6 alkyl, halogen, cyano, deuterium, hydroxy, amino, mercapto, and carbamoyl;
• X is selected from the group consisting of methylene, ethylene, n-propylene, —NH—, —NRz—, and —CRz2Rz3—, wherein each of said methylene, ethylene, and n-propylene is optionally substituted with one or more selected from C1-C6 alkyl, halogen, cyano, deuterium, hydroxy, amino, mercapto, and carbamoyl;
• each of Y and Z is independently selected from the group consisting of —N— and —CRw—;
• W is selected from the group consisting of carbon and sulfur;
• n is 1 or 2, provided that when W is carbon, n is 1;
• and when W is sulfur, n is 2;
• A is selected from the group consisting of 5-12 membered monocyclic or bicyclic aryl or heteroaryl, wherein each of said aryl and heteroaryl is independently optionally substituted with one or more selected from C1-C6 alkyl, halogen, cyano, deuterium, C2-C6 alkenyl, hydroxy, C1-C6 alkoxy, halogen, 3-10 membered cycloalkyl, —NRxRy, amino, mercapto, and carbamoyl, wherein each of said alkyl, alkenyl, alkoxy, and cycloalkyl is independently optionally substituted with one or more selected from C1-C6 alkyl, halogen, cyano, deuterium, hydroxy, amino, mercapto, and carbamoyl;
• L1 is selected from the group consisting of absent, —(C1-C6)alkylene-, and —(C1-C6)alkylene-NH—;
• L2 is selected from the group consisting of absent, and —(C1-C6)alkylene-, wherein said alkylene is optionally substituted with one or more selected from C1-C6 alkyl, and halogen;
• R6 is selected from the group consisting of phenyl and a 3-10 membered heterocyclyl group, wherein each of said phenyl and heterocyclyl group is optionally substituted with one or more selected from C1-C6 alkyl, halogen, cyano, deuterium, oxo, carbamoyl, hydroxy, C1-C6 alkoxy, mercapto, amino, —COOH, —S(O)2NH2, —NR61R62, —NHC(O)R63, —C(O)NR64R65, 5-6 membered heterocyclyl, and —CH2—R66, wherein each of said alkyl, alkoxy, and heterocyclyl is optionally substituted with one or more selected from C1-C6 alkyl, halogen, and deuterium;
• each of R61 and R62 is selected from the group consisting of hydrogen, and C1-C6 alkyl, wherein said alkyl is optionally substituted with C1-C6 alkyl, or
• R61 and R62, taken together with the nitrogen atom to which they are attached, form a nitrogen-containing 5-8 membered heterocyclic group, wherein said heterocyclic group is optionally substituted with one or more selected from C1-C6 alkyl and halogen, wherein said alkyl is optionally substituted with one or more selected from C1-C6 alkyl and halogen;
• R63 is selected from the group consisting of hydrogen, C1-C6 alkyl, NH2, and C2-C6 alkenyl, wherein each of said alkyl and alkenyl is optionally substituted with one or more selected from C1-C6 alkyl and halogen;
• each of R64 and R65 is selected from the group consisting of hydrogen and C1-C6 alkyl, wherein said alkyl is optionally substituted with C1-C6 alkyl, or
• R64 and R65, taken together with the nitrogen atom to which they are attached, form a nitrogen-containing 5-8 membered heterocyclic group, wherein said heterocyclic group is optionally substituted with one or more selected from C1-C6 alkyl and halogen, wherein said alkyl is optionally substituted with one or more selected from C1-C6 alkyl and halogen;
• R66 is a 5-10 membered heterocyclyl group, wherein said heterocyclyl group is optionally substituted with one or more selected from C1-C6 alkyl, halogen, oxo, carbamoyl, and amino;
• each of Rx and Ry is independently selected from the group consisting of hydrogen and C1-C6 alkyl, wherein said alkyl is optionally substituted with one or more selected from C1-C6 alkyl, halogen, cyano, deuterium, hydroxy, amino, mercapto, and carbamoyl;
• Rz1 is C1-C6 alkyl, wherein said alkyl is optionally substituted with one or more selected from C1-C6 alkyl, halogen, cyano, deuterium, hydroxy, amino, mercapto, and carbamoyl;
• Rz2 and Rz3, taken together with the carbon atom to which they are attached, form a 3-6 membered cycloalkane ring, wherein said cycloalkane ring is optionally substituted with one or more selected from C1-C6 alkyl and halogen;
• and
• Rw is selected from the group consisting of hydrogen, C1-C6 alkyl, halogen, cyano, deuterium, C2-C6 alkenyl, C1-C6 alkoxy, 3-10 membered cycloalkyl, —NRxRy, hydroxy, amino, mercapto, and carbamoyl,
• or a tautomer, stereoisomer, prodrug, crystal form, isotopically labeled form, pharmaceutically acceptable salt, hydrate, or solvate thereof.