Bicyclic compounds as cdk inhibitors

A compound of Formula (I):

• or a N-oxide thereof, or a pharmaceutically acceptable salt thereof, or a stereoisomer thereof, or a tautomer, or a deuterated analog thereof, or a prodrug thereof, wherein:
• n1 is 0, 1, or 2;
• n2 is 1, 2 or 3;
• n3 is 0, 1, or 2;
• n4 is 0, 1, 2, 3 or 4;
• n5 and n6 are each independently 0 or 1, provided that n5 and n6 are not 0 at the same time;
• each of is independently a single bond or double bond, provided that two double bonds are not connected directly;
• X1, X2, X3 and X4 are each independently selected from N, C, S(═O)2 or S(═O), wherein each Nis independently substituted with 0 or 1 RXa groups as allowed by valence, and each C is independently substituted with one or two RAb groups as allowed by valence;
• RXa is each independently selected from hydrogen, —C1-C8alkyl, —C2-C8alkenyl, —C2-C8alkynyl, —C3-C8cycloalkyl, 3- to 12-membered heterocyclyl, —C6-C12aryl or 5- to 12-membered heteroaryl, wherein each of said —C1-C8alkyl, —C2-C8alkenyl, —C2-C8alkynyl, C3-C8cycloalkyl, 3- to 8-membered heterocyclyl, C6-C12aryl or 5- to 12-membered heteroaryl is optionally substituted with at least one substituent RXaa;
• RXaa is each independently selected from hydrogen, deuterium, halogen, —C1-C8alkyl, —C2-C8alkenyl, —C2-C8alkynyl, —C3-C8cycloalkyl, 3- to 8-membered heterocyclyl, —C6-C12aryl, 5- to 12-membered heteroaryl, oxo (═O), —ORXab, —CN, —SO2RXab, —SO2NRXabRXac, —C(O)RXab, —CO2RXab, —C(O)NRXabRXac, —NRXabRXac, —NRXabCORXac, —NRXabCO2RXac or —NRXabSO2RXac, wherein each of said —C1-C8alkyl, —C2-C8alkenyl, —C2-C8alkynyl, —C1-C8alkoxy, —C3-C8cycloalkyl, 3- to 8-membered heterocyclyl, —C6-C12aryl or 5- to 12-membered heteroaryl is optionally substituted with halogen, —C1-C8alkyl, —C2-C8alkenyl, —C2-C8alkynyl, —C3-C8cycloalkyl, 3- to 8-membered heterocyclyl, C6-C12aryl, 5- to 12-membered heteroaryl, oxo (═O), —CN, —ORXad, —SO2RXad, —SO2NRXadRXac, —C(O)RXad, —CO2RXad, —C(O)NRXadRXas, —NRXadRXac, —NRXadCORXae, —NRXadCO2RXae or —NRXadSO2RXae;
• RXab, RXac, RXad and RXae are each independently selected from hydrogen, deuterium, —C1-C8alkyl, —C2-C8alkenyl, —C2-C8alkynyl, C3-C8cycloalkyl, 3- to 8-membered heterocyclyl, C6-C12aryl, or 5- to 12-membered heteroaryl, wherein each of said —C1-C8alkyl, —C2-C8alkenyl, —C2-C8alkynyl, C3-C8cycloalkyl, 3- to 8-membered heterocyclyl, C6-C12aryl, or 5- to 12-membered heteroaryl is optionally substituted with halogen, —C1-C8alkyl, —C2-C8alkenyl, —C2-C8alkynyl, C3-C8cycloalkyl, 3- to 8-membered heterocyclyl, C6-C12aryl, 5- to 12-membered heteroaryl, oxo (═O), —CN, —OH, or —C1-C8alkoxyl;
• RXb is each independently selected from hydrogen, halogen, —C1-C8alkyl, C3-C8cycloalkyl, 3- to 8-membered heterocyclyl, C6-C12aryl, 5- to 12-membered heteroaryl, oxo (═O), —NRXbaRXbb, —ORXba, —SRXba, —SO2RXba, —SO2NRXbaRXbb, —C(O)RXba, —CO2RXba, —C(O)NRXbaRXbb, —NRXbaCORXbb, —NRXbaCO2RXbb or —NRXbaSO2RXbb or —CN, wherein each of said —C1-C8alkyl, C3-C8cycloalkyl, 3- to 8-membered heterocyclyl, C6-C12aryl, or 5- to 12-membered heteroaryl is optionally substituted with at least one RXbe, or
• two RAD together with the atom(s) to which they are attached, form a 3- to 12-membered ring, said ring comprising 0-3 heteroatoms independently selected from nitrogen, oxygen or optionally oxidized sulfur as ring member(s);
• said ring is optionally substituted with at least one substituent RXbc, RXba and RXbb are each independently selected from hydrogen, deuterium, —C1-C8alkyl, —C2-C8alkenyl, —C2-C8alkynyl, C3-C8cycloalkyl, 3- to 8-membered heterocyclyl, C6-C12aryl, or 5- to 12-membered heteroaryl, wherein each of said —C1-C8alkyl, —C2-C8alkenyl, —C2-C8alkynyl, C3-C8cycloalkyl, 3- to 8-membered heterocyclyl, C6-C12aryl, or 5- to 12-membered heteroaryl is optionally substituted with at least one substituent RXbd, RXbc and RXbd are each independently selected from hydrogen, deuterium, halogen, hydroxy, -C1-C8alkyl, —C1-C8alkoxy, —C2-C8alkenyl, —C2-C8alkynyl, C3-C8cycloalkyl, 3- to 8-membered heterocyclyl, C6-C12aryl, 5- to 12-membered heteroaryl, oxo (═O), —NRXbeRXbf, —ORXbe, —SRXbe, —SO2RXbe, —SO2NRXbeRXbf, —C(O)RXbe, —CO2RXbe, —C(O)NRXbeRXbf, —NRXbeCORXbf, —NRXbeCOO2RXbf or —NRXbeSO2RXbf or —CN;
• RXbe and RXbf are each independently selected from —C1-C8alkyl, —C2-C8alkenyl, —C2-C8alkynyl, C3-C8cycloalkyl, 3- to 8-membered heterocyclyl, C6-C12aryl, or 5- to 12-membered heteroaryl;
• Y1, Y2 and Y3 are each independently selected from O, C or N, wherein C and N are independently substituted with 1 or 2 R5 groups or hydrogen atoms as allowed by valence;
• Q is selected from O or NRQ;
• R1, R2, R3 and R° are each independently selected from hydrogen, —C1-C8alkyl, —C2-C8alkenyl, —C2-C8alkynyl, —C3-C8cycloalkyl, 3- to 8-membered heterocyclyl, —C6-C12aryl or 5- to 12-membered heteroaryl, wherein each of said —C1-C8alkyl, —C2-C8alkenyl, —C2-C8alkynyl, C3-C8cycloalkyl, 3- to 8-membered heterocyclyl, C6-C12aryl or 5- to 12-membered heteroaryl is optionally substituted with at least one substituent R1a;
• or
• R1 and R2 together with the atom to which they are attached, form a 3- to 12-membered ring, said ring comprising 0-3 additional heteroatoms independently selected from nitrogen, oxygen or optionally oxidized sulfur as ring member(s);
• said ring is optionally substituted with at least one substituent R1bb;
• R1a and R1b are each independently selected from hydrogen, halogen, —C1-C8alkyl, —C2-C8alkenyl, —C2-C8alkynyl, —C3-C8cycloalkyl, 3- to 8-membered heterocyclyl, —C6-C12aryl, 5- to 12-membered heteroaryl, oxo (═O), —OR1c, —CN, —SO2R1c, —SO2NR1cR1d, —C(O)R1c, —CO2R1c, —C(O)NR1cR1d, —NR1cR1d, —NR1cCOR1d, —NR1cCOR21d or —NR1cSO2R1d, wherein each of —C1-C8alkyl, —C2-C8alkenyl, —C2-C8alkynyl, —C1-C8alkoxy, —C3-C8cycloalkyl, 3- to 8-membered heterocyclyl, —C6-C12aryl or 5- to 12-membered heteroaryl is optionally substituted with halogen, —C1-C8alkyl, —C2-C8alkenyl, —C2-C8alkynyl, —C3-C8cycloalkyl, 3- to 8-membered heterocyclyl, C6-C12aryl, 5- to 12-membered heteroaryl, oxo (═O), —CN, —OR1e, —SO2R1e, —SO2NR1eR1f, —C(O)R1e, —CO2R1f, —C(O)NR1eR1f, —NR1eR1f, —NR1eCOR1f, —NR1eCO2R1f or —NR1eSO2R1f;
• R1e, R1d, R1e and R1f are each independently selected from hydrogen, —C1-C8alkyl, —C2-C8alkenyl, —C2-C8alkynyl, C3-C8cycloalkyl, 3- to 8-membered heterocyclyl, C6-C12aryl, or 5- to 12-membered heteroaryl;
• R4 and R5 are each independently selected from hydrogen, halogen, —C1-C8alkyl, —C2-C8alkenyl, —C2-C8alkynyl, —C1-C8alkoxy, or —C3-C8cycloalkyl;
• z1, Z2 and Z3 are each independently selected from —CRZ, or N;
• R2, at each occurrence, is independently selected from hydrogen, halogen, —C1-C8alkyl, C3-C8cycloalkyl, 3- to 8-membered heterocyclyl, C6-C12aryl, 5- to 12-membered heteroaryl, —NRZaRZb, —ORZa, —SRZa, —SO2RZa, —SO2NRZaR2b, C(O)RZa, —CO2RZa, —C(O)NRZaR2b, —NRZaCORZb, —NRZaCO2RZb or —NRZaSO2RZb or —CN, wherein each of said —C1-C8alkyl, C3-C8cycloalkyl, 3- to 8-membered heterocyclyl, C6-C12aryl, or 5- to 12-membered heteroaryl is optionally substituted with at least one RZc;
• RZa and R2b are each independently selected from hydrogen, —C1-C8alkyl, —C2-C8alkenyl, —C2-C8alkynyl, C3-C8cycloalkyl, 3- to 8-membered heterocyclyl, C6-C12aryl, or 5- to 12-membered heteroaryl, wherein each of said —C1-C8alkyl, —C2-C8alkenyl, —C2-C8alkynyl, C3-C8cycloalkyl, 3- to 8-membered heterocyclyl, C6-C12aryl, or 5- to 12-membered heteroaryl is optionally substituted with at least one substituent RZd,
• RZc and RZd are each independently selected from halogen, hydroxy, —C1-C8alkyl, —C1-C8alkoxy, —C2-C8alkenyl, —C2-C8alkynyl, C3-C8cycloalkyl, 3- to 8-membered heterocyclyl, C6-C12aryl, 5- to 12-membered heteroaryl, oxo (═O), —NRZeRZf, —ORZe, —SRZe, —SO2RZe, —SO2NRZeRZf, —C(O)RZe, —CO2RZe, —C(O)NRZeRZf, —NRZeCORZf, —NRZeCO2RZf or —NRZeSO2RZf or —CN;
• Rze and RZf are each independently selected from —C1-C8alkyl, —C2-C8alkenyl, —C2-C8alkynyl, C3-C8cycloalkyl, 3- to 8-membered heterocyclyl, C6-C12aryl, or 5- to 12-membered heteroaryl.