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US 2026/0297075 A1Published application
N-cyanopyrrolidines with activity as usp30 inhibitors
AssigneeMission Therapeutics Limited
InventorsChristopher Andrew LUCKHURST, Mark Ian KEMP, Paul William THOMPSON
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Abstract
The present invention relates to a class of N-cyanopyrrolidines with activity as inhibitors of the deubiquitylating enzyme USP30, having utility in a variety of therapeutic areas, including conditions involving mitochondrial dysfunction, cancer and fibrosis:
Claims31
A compound of formula (I), which is selected from formula (I)(i) and formula (I) (ii):
- or a tautomer thereof, or a pharmaceutically acceptable salt of said compound or tautomer,
- wherein:
- R1 is selected from (C1-C4)alkyl, (C1-C4) fluoroalkyl and CH2OCH3;
- R2 is selected from (C1-C4)alkyl, CF3 and cyclopropyl;
- and
- R3, R4 and R5 are each independently selected from hydrogen and halogen.
3 more elements
19-21. (canceled)
Dependencies are inferred from the claim text.