Cyclopentylpyrazolamine derivative and use thereof

A compound of formula (I), an isomer thereof, or a pharmaceutically acceptable salt thereof,

• wherein
• X1, X2, and X3 are each independently selected from the group consisting of N and C(Ra);
• Z1, Z2, and Z3 are each independently selected from the group consisting of O, S, N, N(Rb), S(O), S(O)2, C(O), C(Ra), and C(RaRa);
• L1 and L2 are each independently selected from the group consisting of a single bond, —N(Rb)—, —N═, —O—, —S—, —(CH2)m—, —(CD2)m-, —(CHD)m-, —C(═O)—, —S(═O)—, —S(═O)2—, —S(═O)(═N(Rb))—, —S(═O)(Rc)—, —P(═O)(Rc)—, and —P(═O)(NRbRb)—;
• R1 is selected from the group consisting of H, deuterium, C1-3 alkyl, C1-3 alkoxy, —NH2, —NH(C1-3 alkyl), —N(C1-3 alkyl)2, C3-6 cycloalkyl, C3-6 cycloalkenyl, 3- to 6-membered heterocyclyl, phenyl, and 5- to 6-membered heteroaryl, the C1-3 alkyl or C1-3 alkoxy being optionally independently substituted with 1, 2, or 3 Rd, and the C3-6 cycloalkyl, C3-6 cycloalkenyl, 3- to 6-membered heterocyclyl, phenyl, or 5- to 6-membered heteroaryl being optionally independently substituted with 1 or more Re;
• A is selected from the group consisting of
• and 3- to 6-membered heterocyclyl containing 1 or 2 N atoms, the 3- to 6-membered heterocyclyl being optionally independently substituted with 1 or more Rz;
• R2, R3, and R4 are each independently selected from the group consisting of H, deuterium, halogen, OH, CN, NH2, C1-3 alkyl, C1-3 alkoxy, C3-6 cycloalkyl, C3-6 cycloalkenyl, and 3- to 6-membered heterocyclyl, the C1-3 alkyl, C1-3 alkoxy, C3-6 cycloalkyl, C3-6 cycloalkenyl, or 3- to 6-membered heterocyclyl being optionally independently substituted with 1 or more Rz;
• or, R2 and R3, together with the carbon atom linked thereto, form C3-6 cycloalkyl, C3-6 cycloalkenyl, or 3- to 6-membered heterocyclyl, and R4 is selected from the group consisting of H, deuterium, halogen, OH, CN, NH2, C1-3 alkyl, and C1-3 alkoxy, the C1-3 alkyl, C1-3 alkoxy, C3-6 cycloalkyl, C3-6 cycloalkenyl, or 3- to 6-membered heterocyclyl being optionally independently substituted with 1 or more Rz;
• or, R2, R3, and R4, together with the carbon atom linked thereto, form C5-8 bicycloalkyl or 5- to 8-membered heterobicycloalkyl, the C5-8 bicycloalkyl or 5- to 8-membered heterobicycloalkyl being optionally independently substituted with 1 or more R2;
• Ra is each independently selected from the group consisting of hydrogen, deuterium, halogen, OH, CN, NH2, COOH, NO2, C1-3 alkyl, C1-3 alkoxy, C1-3 alkoxy C1-3 alkylene, C1-3 alkylamino, and (C1-3 alkyl)2 amino, the C1-3 alkyl or C1-3 alkoxy being optionally independently substituted with 1 or more Rx;
• or, the two Ra in C(RaRa), together with the carbon atom linked thereto, form C3-6 cycloalkyl, C3-6 cycloalkenyl, or 3- to 6-membered heterocyclyl, the C3-6 cycloalkyl, C3-6 cycloalkenyl, or 3- to 6-membered heterocyclyl being optionally independently substituted with 1 or more Ry;
• Rb is each independently selected from the group consisting of H, C1-3 alkyl, C1-3 alkoxy, —C(═O)H, —S(═O)2C1-3 alkyl, C3-6 cycloalkyl, C3-6 cycloalkenyl, and 3- to 6-membered heterocyclyl, the C1-3 alkyl or C1-3 alkoxy being optionally independently substituted with 1, 2, or 3 Rx, and the C3-6 cycloalkyl, C3-6 cycloalkenyl, or 3- to 6-membered heterocyclyl being optionally independently substituted with 1 or more Ry;
• Rc is selected from the group consisting of halogen, OH, CN, and C1-3 alkyl, the C1-3 alkyl being optionally independently substituted with 1 or more Rx;
• Rd is each independently selected from the group consisting of deuterium, halogen, OH, CN, and NH2;
• Re is each independently selected from the group consisting of deuterium, halogen, OH, CN, NH2, ═O, C1-3 alkyl, and C1-3 alkoxy, the C1-3 alkyl or C1-3 alkoxy being optionally independently substituted with 1 or more Rx;
• Rx is each independently selected from the group consisting of deuterium, halogen, OH, CN, and NH2;
• Ry is each independently selected from the group consisting of deuterium, halogen, OH, CN, NH2, ═O, C1-3 alkyl, and C1-3 alkoxy, the C1-3 alkyl or C1-3 alkoxy being optionally independently substituted with 1 or more substituents selected from the group consisting of deuterium, halogen, OH, CN, and NH2;
• Rz is each independently selected from the group consisting of deuterium, halogen, OH, CN, NH2, C1-3 alkyl, and C1-3 alkoxy, the C1-3 alkyl or C1-3 alkoxy being optionally independently substituted with 1 or more substituents selected from the group consisting of deuterium, halogen, OH, CN, and NH2;
• m is selected from the group consisting of 1, 2, and 3;
• the carbon atom with “*” is a chiral carbon atom present in a form of a single (R) or (S) enantiomer or in a form enriched with one enantiomer;
• or, L1, L2, R1, R2, R3, R4, Ra, Rb, Rc, Rd, Re, Rx, Ry, or Rz is each independently optionally substituted with one or more substituents.