An aromatic substituent-containing heteroaryl- or phenyl-imidazole compound, a stereoisomer, a hydrate, a solvate, a pharmaceutically acceptable salt or a prodrug thereof, wherein the compound has a structure represented by the following general formula IA or general formula IB:
- wherein, X and Y each independently represent C or N;
- R1, R2 and R3 are each independently selected from a group consisting of hydrogen, deuterium, tritium, halogen, substituted or unsubstituted straight-chain alkyl, substituted or unsubstituted branched-chain alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, cyano, trifluoromethyl, alkoxy, cycloalkyloxy, aryloxy, substituted or unsubstituted amino, substituted or unsubstituted thiol, substituted or unsubstituted sulfonyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted heteroalkenyl, substituted or unsubstituted heteroalkynyl, substituted or unsubstituted aryl, and substituted or unsubstituted heteroaryl, or isotopic substituents thereof;
- R9 is selected from a group consisting of hydrogen, deuterium, tritium, halogen, substituted or unsubstituted straight chain alkyl, substituted or unsubstituted branched chain alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, cyano, trifluoromethyl, alkoxy, cycloalkyloxy, aryloxy, substituted or unsubstituted amino, substituted or unsubstituted thiol, substituted or unsubstituted sulfonyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted heteroalkenyl, substituted or unsubstituted heteroalkynyl, substituted or unsubstituted aryl, and substituted or unsubstituted heteroaryl, or isotopic substituents thereof, or a prodrug group of a parent structure;
- Ar1 and Ar2 are each independently selected from a group consisting of substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl;
- wherein, at least one unsaturated carbon atom in the heteroaryl or phenyl ring of the heteroaryl- or phenyl-imidazole compound is directly connected to an unsaturated carbon atom of Ar1, and a carbon atom adjacent to two N atoms in the imidazole ring of the heteroaryl- or phenyl-imidazole compound is directly connected to an unsaturated carbon atom of Ar2.